Who We Are

The Department of Cell and Regenerative Biology is committed to understanding the fundamental mechanisms by which living systems operate at cellular and molecular levels of organization. By embracing a wide range of contemporary and emerging approaches and experimental systems, we seek to define signaling and regulatory pathways that provide the basis for understanding, diagnosis and treatment of human disease. Basic research is the centerpiece of the Department and serves as the driving force behind teaching and training efforts. The overarching research interests of the Department are highly interdisciplinary, emphasizing molecular, cellular and systems approaches to describe biological processes in molecular terms. To maintain its excellence and stature, the Department is currently focusing on existing strengths in four research areas: Cell and Molecular Biology, Developmental Biology, Stem Cell and Regenerative Biology, and Cardiovascular Biology.

In Memoriam

We have lost an accomplished leader, insightful scientist, treasured colleague and inspirational friend. Patti Keely passed away Saturday evening, June 24th at home with family and hospice care.

A memorial service in celebration of Patti's life was held on Monday, July 10.

Announcement from the School of Medicine and Public Health

Recent photo of the Keely lab group.


Recent Publications

* Muir AM, Massoudi D, Nguyen N, Keene DR, Lee SJ, Birk DE, Davidson JM, Marinkovich MP, Greenspan DS. BMP1-like proteinases are essential to the structure and wound healing of skin. Matrix Biol. 2016 Jun 27. (Epub before print)

*Lee S, Shatadal S, Griep AE. Dlg-1 Interacts With and Regulates the Activities of Fibroblast Growth Factor Receptors and EphA2 in the Mouse Lens. Invest Ophthalmol Vis Sci. 2016 57:707-18.

*Plavicki JS, Squirrell JM, Eliceiri KW, Boekhoff-Falk G. Expression of the Drosophila homeobox gene, Distal-less, supports an ancestral role in neural development. Dev Dyn. 2016 245:87-95.

*Brody MJ, Lee Y. The Role of Leucine-Rich Repeat Containing Protein 10 (LRRC10) in Dilated Cardiomyopathy. Front Physiol. 2016 7:337.

*Lee J, Tong T, Duan H, Foong YH, Musaitif I, Yamazaki T, Jefcoate C. Regulation of StAR by the N-terminal Domain and Coinduction of SIK1 and TIS11b/Znf36l1 in Single Cells. Front Endocrinol (Lausanne). 2016 7:107.

*A new publication from Gary Lyons, Tim Kamp, Karen Downs and collaborators "Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell" has just appeared in Stem Cells .

* Emery Bresnick's group's paper "GATA factor-dependent positive-feedback circuit in acute myeloid leukemia cells" has recently been published in Cell Reports.

* Highlighted in the July 1, 2016 issue of Molecular Biology of the Cell is a paper from Beth Weaver's lab:"High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation".

Patricia Keely Memorial Fund - Contribute here.

Upcoming Events

11/8/17, 12:30-1:30 pm, CRB Faculty Meeting, 4571 WIMR

12/6/17, 1-2 pm, Xiaolei Xu Seminar, 6571 WIMR

12/13/17, 12:30-1:30 pm, CRB Faculty Meeting, 4571 WIMR

Future Seminars

News and Awards

*Welcome to Junsu Kang, who just joined CRB as an Assistant Professor. There will be a welcome reception for Junsu on Wednesday, October 11 at noon in 4571 WIMR.

*Congratulations to Assistant Professor Ricki Colman on her recent publication in Nature Communications. This work is highlighted in NIH Research Matters "The impacts of calorie restriction on lifespan have been known for decades, but thanks to modern quantitative techniques, we are able to show for the first time a striking slowing down of epigenetic drift as lifespan increases."

*Welcome to our newest Assistant Professor, Ahmed Mahmoud! Ahmed joined CRB on September 1. Please stop by his office in 4557 WIMR to say hello! There will be a welcome reception for Ahmed on September 13 (see events listing above).

*Congratulations to several new PhD graduates! Zach Gregorich (Ying Ge's lab) and Adriana Rodriguez (Karen Downs' lab) both completed their PhDs in August. Earlier this year (May 2017), Lucas Tomko completed his PhD with Patti Keely.

*Our new Department Administrator, Jacalyn McHugh, joined CRB on June 1. Jackie worked as the Research Operations Manager for the Regenerative Medicine Institute at Cedars-Sinai Medical Center in Los Angeles, CA since 2010.  Prior to that time, she worked for Clive Svendsen’s Laboratory at UW-Madison from 2003 – 2009, Karen Downs’ Laboratory (2000-2003) and Fred Blattner’s Laboratory (1997-1999). 

*Congratulations to Vege (Wenxuan Cai) on receiving an American Heart Association predoctoral fellowship! Vege is a graduate student in Ying Ge's lab.

*Welcome to our newest faculty member, Ricki Colman. Ricki joined the CRB faculty in March and will continue her groundbreaking research on nutrition and longevity at the Wisconsin National Primate Research Center.

*Congratulations to the students of CRB faculty and affiliates who gave research presentations yesterday in the Undergraduate Symposium 2017.  These students are Brenna Bomkamp and Ryan Gigstad (Patti Keely lab); Cayla Guerra (Grace Boekhoff-Falk lab); Rachel Acevedo and Veronica Porubsky (Pam Kreeger lab); Cesar Martinez (Rupa Sridharan lab); Lindsey Waite and Maddie Kruk (Joe Kemnitz lab); Cyrus Colah (Ying Ge lab); Michael Bray, Jieun Heo and Kailee Kujawski (Darcie Moore lab); Jon Doenier (Judith Kimble lab).  Thanks to each of you for a job well done!

*Congratulations to Beth Weaver on receiving the H.I. Romnes Faculty Fellowship.

* Congratulations to Dan Greenspan and his group on their publication in Nature Communications: "α3 Chains of type V collagen regulate breast tumour growth via glypican-1"

* Congratulations to Joe Kemnitz and Ricki Colman on their publication in Nature Communications: "Caloric restriction improves health and survival of rhesus monkeys"

*Phillip Newmark is the first recipient of the Burnell R. Roberts endowed chair in Regenerative Biology. Phil and his eight-person team are working to better understand stem-cell-based regeneration processes, an important step toward potential therapies to repair or replace damaged human tissue.

*Professor Phillip Newmark , who has recently joined the Morgridge Institute and the Zoology Department, will have an affiliate appointment with CRB.

* Assistant Professor Darcie Moore has recently joined the Department of Neuroscience, and she will have an affililate appointment with CRB. Welcome Dr. Moore!

* Four undergraduates working with CRB faculty have received a Hilldale Faculty/Undergraduate Research Award for the 2016-17 academic year. They are:

  • Cayla Guerra (Prof. Boekhoff-Falk)
  • Cyrus Colah (Prof. Ge)
  • Jaime Brown and Cesar Martinez (Prof. Sridharan)

* Jun Wan, Physiology Graduate Training Program student with Beth Weaver, has been awarded a predoctoral fellowship from the American Heart Association starting July 1, 2016. Congratulations Jun!

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