Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.

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Ying Ge, PhD

Assistant Professor Department of Cell and Regenerative Biology
Assistant Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison
Biographical Sketch

Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology
Faculty trainer, UW Molecular and Environmental Toxicology Training Program
Faculty trainer, UW Physiology Training Program

    News and Updates

  • Nov. 2014, Tania Guardado, a synthetic chemist, has joined the Ge and Jin Group. Welcome!
  • Nov. 2014, Lynn has been promoted to Assistant Scientist. Congratulations!
  • Nov. 2014, Santosh has found a job in industry. Congratulations!
  • Oct. 2014, Cadet Scotty from the Molecular and Cellular Pharmacology Program started rotation in the Ge Group.
  • Oct. 14, 2014, Group trip to the Devil's Lake [Photos]
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Most Recent Publications

  1. Ye, L.; Chang, Y. H.; Xiong Q.; Zhang P.; Somasundaram, P.; Lepley M.; Swingen C.; Su, L.; Wendel, J. S.; Guo, J.; Jang, A.; Rosenbush, D.; Zhang, L.; Greder, L.; Dutton, J. R.; Zhang, J.; Kamp, T. J.; Kaufman, D.S.; Ge, Y.; Zhang, J. Myocardial repair in a porcine model using tri-lineage cardiovascular cell populations derived from human induced pluripotent stem cells, Cell Stem Cell, Accepted.
  2. Peng, Y.; Gregorich Z. R.; Valeja, S. G.; Zhang, H.; Cai, W.; Chen, Y.; Guner, H.; Chen, A. J.; Schwahn, D. J.; Hacker, T. A.; Liu, X.; Ge, Y. Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction, Mol. Cell. Proteomics, Epub ahead of print. (Ge, Y. Corresponding author) Article
  3. Xiu, L.; Valeja, S. G.; Alpert, A. J.; Jin, S.; Ge, Y. Effective protein separation by coupling hydrophobic interaction and reverse phase chromatography for top-down proteomics, Anal. Chem. Epub ahead of print. (Ge, Y. Corresponding author) Article
  4. Valkevich, E. M.; Sanchez, N.; Ge, Y.; Strieter, E. R. Middle-down mass spectrometry enables characterization of branched ubiquitin chains, Biochemistry, 2014, 53, 4979−4989. Article
  5. Peng, Y.; Ayaz-Guner, S.; Yu, D.; Ge, Y. Top-down mass spectrometry of cardiac myofilament proteins in health and disease, Proteomics Clin. Appl. Epub ahead of print. (Ge, Y. Corresponding author) Article
  6. Gregorich Z. R.; Ge, Y. Top-down proteomics in health and disease: challenges and opportunities, Proteomics, 2014, 14, 1195-1210. (Ge, Y. Corresponding author) *This is an invited article for a special issue on “Top-down proteomics”. Article
  7. Gregorich Z. R.; Chang, Y.-W.; Ge, Y. Proteomics in heart failure: top-down or bottom-up? Pflugers Arch. Eur. J. Physiol. 2014, 466, 1199-1209. (Ge, Y. Corresponding author) *This is an invited review for a special issue on “Heart Failure”. Article
  8. Witayavanitkul, N.; Sarkey, J.; Mou, Y. A.; Kuster, D.W.D.; Khairallah, R. J.; Govindan, S.; Chen, X.; Ge, Y.; Rajan, S.; Wieczorek, D. F.; Irving, T.; de Tombe, P. P.; Sadayappan, S. Myocardial infarction-induced N-terminal fragment of cMyBP-C impairs myofilament function in human left ventricular myofibrils, J. Biol. Chem. 2014, 289, 8818-8827 Article
  9. Chen, S.; Zhu, P.; Guo, H.; Wang, Y.; Ma, Y.; Wang, J.; Gao, J.; Chen, J.; Ge, Y.; Zhuang, J.; Li, J. a-1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I, Life Sci., 2014, 98, 75-82. Article
  10. Guner, H.; Close, P.L.; Cai, W.; Zhang, H.; Peng, Y.; Chen, Y.; Gregorich, Z. R. Ge, Y. MASH Suite: A user-friendly and versatile software interface for high-resolution mass spectrometry data interpretation and visualization, J. Am. Soc. Mass Spectrom. 2014, 25, 464-470. (Ge, Y. Corresponding author) Article

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