Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.

Read more...


Ying Ge, PhD

Associate Professor, Department of Cell and Regenerative Biology
Associate Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison
Biographical Sketch

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology
Faculty trainer, UW Molecular and Environmental Toxicology Training Program
Faculty trainer, UW Physiology Training Program

    News and Updates

  • Aug. 2015, the Ge Group attended the Wisconsin Human Proteomics Symposium, 2015. [Photos coming soon!]
  • Jul. 2015, Serife has found an assistant professor position in Turkey. Congratulations!
  • Jul. 2015, joint group summer party with the Jin Group in Ying and Song's house. [ Photos]
  • Jul. 2015, Liming Wei, a visiting scholar, has joined the Ge Group. Welcome!
  • Jul. 2015, Ziqing Lin, a post-doctoral fellow, has joined the Ge Group. Welcome!
  • Jun. 2015, the Ge Group attended the 63rd ASMS conference in St. Louis. [ Photos]
  • Apr. 2015, Dr. Ying Ge has been promoted to Associate Professor.
  • Apr. 2015, Nicole is awarded with the CVRC pre-doctoral fellowship. Congratulations!
  • Apr. 2015, Tania is awarded with the NIH NRSA post-doctoral fellowship. Congratulations!
         More

Most Recent Publications

  1. Gregorich Z. R.; Peng, Y.; Wolff, J. J.; Guo, W.; Guner, H.; Doop, J.; Hacker, T. A.; Ge, Y. Comprehensive assessment of regional and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry, J. Mol. Cell. Cardiol. Accepted. (Ge, Y. Corresponding author)
  2. Chen, Y.-C.; Ayaz-Guner, S.; Peng, Y.; Lane, M. L.; Locher, M.; Larsson, L.; Kohmoto, T.; Moss, R. L.; Ge, Y. A top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker, Anal Chem. Epub ahead of print. (Ge, Y. Corresponding author)
  3. Chang, Y. H.; Ye, L.; Cai, W.; Lee, Y.; Guner, H.; Lee, Y.; Kamp, T. J.; Zhang, J.; Ge, Y. Quantitative Proteomics Reveals Differential Regulation of Protein Expression in Recipient Myocardium after Trilineage Cardiovascular Cell Transplantation. Proteomics. 2015, 15, 2560-2567 doi: 10.1002/pmic.201500131. (Ge, Y. Corresponding author)
  4. Valeja, S. G.; Xiu, L.; Gregorich, Z. R.; Guner, H.; Jin, S.; Ge, Y. Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics. Anal Chem. 2015, 87(10), 5363-71. (Ge, Y. Corresponding author)
  5. Hwang, L.; Ayaz-Guner, S.; Cai, W.; Gregorich Z. R.; Jin, S.; Ge, Y. Specific enrichment of phosphoproteins using functionalized multivalent nanoparticles, J. Am. Chem. Soc., 2015, 87, 5363-5371. (Ge, Y. Corresponding author)
  6. Chang, Y.; Gregorich Z. R.; Chen, A. J.; Hwang L.; Guner, H.; Yu, D.; Zhang, J.; Ge, Y. New mass spectrometry-compatible degradable surfactant for tissue proteomics, J. Proteome Res., 2015, 14, 1587-1599. (Ge, Y. Corresponding author)
  7. Chen, Y.; Sumandea, M. P.; Larsson, L.; Moss, R. L.; Ge, Y. Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry, J. Muscle Res. Cell Motil., 2015, 36, 168-181. (Ge, Y. Corresponding author)
  8. Ye, L.; Chang, Y. H.; Xiong Q.; Zhang P.; Somasundaram, P.; Lepley M.; Swingen C.; Su, L.; Wendel, J. S.; Guo, J.; Jang, A.; Rosenbush, D.; Zhang, L.; Greder, L.; Dutton, J. R.; Zhang, J.; Kamp, T. J.; Kaufman, D.S.; Ge, Y.; Zhang, J. Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells, Cell Stem Cell, 2014, 15, 750-761.
  9. Peng, Y.; Gregorich Z. R.; Valeja, S. G.; Zhang, H.; Cai, W.; Chen, Y.; Guner, H.; Chen, A. J.; Schwahn, D. J.; Hacker, T. A.; Liu, X.; Ge, Y. Top-down proteomics reveals concerted reductions in myofilament and Z-disc protein phosphorylation after acute myocardial infarction, Mol. Cell. Proteomics, 2014, 13, 2752-2764. (Ge, Y. Corresponding author)
  10. Xiu, L.; Valeja, S. G.; Alpert, A. J.; Jin, S.; Ge, Y. Effective protein separation by coupling hydrophobic interaction and reverse phase chromatography for top-down proteomics, Anal. Chem. 2014, 86, 7899-7906. (Ge, Y. Corresponding author)
  11. Valkevich, E. M.; Sanchez, N.; Ge, Y.; Strieter, E. R. Middle-down mass spectrometry enables characterization of branched ubiquitin chains, Biochemistry, 2014, 53, 4979−4989.
  12. Peng, Y.; Ayaz-Guner, S.; Yu, D.; Ge, Y. Top-down mass spectrometry of cardiac myofilament proteins in health and disease, Proteomics Clin. Appl. 2014, 8, 554–568. (Ge, Y. Corresponding author)
  13. Gregorich Z. R.; Ge, Y. Top-down proteomics in health and disease: challenges and opportunities, Proteomics, 2014, 14, 1195-1210. (Ge, Y. Corresponding authoer)
  14. Gregorich Z. R.; Chang, Y. H.; Ge, Y. Proteomics in heart failure: top-down or bottom-up? Pflugers Arch. Eur. J. Physiol. 2014, 466, 1199-1209. (Ge, Y. Corresponding author)
  15. Witayavanitkul, N.; Sarkey, J.; Mou, Y. A.; Kuster, D.W.D.; Khairallah, R. J.; Govindan, S.; Chen, X.; Ge, Y.; Rajan, S.; Wieczorek, D. F.; Irving, T.; de Tombe, P. P.; Sadayappan, S. Myocardial infarction-induced N-terminal fragment of cMyBP-C impairs myofilament function in human left ventricular myofibrils, J. Biol. Chem. 2014, 289, 8818-8827.
  16. Chen, S.; Zhu, P.; Guo, H.; Wang, Y.; Ma, Y.; Wang, J.; Gao, J.; Chen, J.; Ge, Y.; Zhuang, J.; Li, J. a-1 catalytic subunit of AMPK modulates contractile function of cardiomyocytes through phosphorylation of troponin I, Life Sci., 2014, 98, 75-82.
  17. Guner, H.; Close, P.L.; Cai, W.; Zhang, H.; Peng, Y.; Chen, Y.; Gregorich, Z. R.; Ge, Y. MASH Suite: A user-friendly and versatile software interface for high-resolution mass spectrometry data interpretation and visualization, J. Am. Soc. Mass Spectrom. 2014, 25, 464-470. (Ge, Y. Corresponding authoer)

     More publications