Welcome to Ge Research Group!

The Ge lab at UW-Madison aims to understand the molecular and cellular mechanisms underlying cardiovascular diseases via systems biology approaches featuring cutting-edge high-resolution mass spectrometry (MS)-based comparative proteomics and metabolomics in conjunction with biochemical/biological/physiological functional studies.


Ying Ge, PhD

Associate Professor, Department of Cell and Regenerative Biology
Associate Professor, Department of Chemistry
Director of Mass Spectrometry
Human Proteomics Program
School of Medicine and Public Health
University of Wisconsin-Madison
Biographical Sketch

Faculty trainer, Translational Cardiovascular Science Training Program
Faculty trainer, Chemistry-Biology Interface Training Program
Faculty trainer, UW Graduate Program in Cellular and Molecular Biology
Faculty trainer, UW Graduate Program in Molecular and Cellular Pharmacology
Faculty trainer, UW Graduate Program in Cellular and Molecular Pathology
Faculty trainer, UW Molecular and Environmental Toxicology Training Program
Faculty trainer, UW Physiology Training Program

    News and Updates

  • Mar. 2017, Bifan Chen is awarded with the 2017 ASMS (American Society for Mass Spectrometry) Graduate Student Award. Congratulations!
  • Feb. 1, 2017, Trisha Tucholski is awarded a National Institutes of Health (NIH) Chemistry-Biology Interface Training Program (CBI) Traineeship. Congrats Trisha!

  • Nov. 2016, 1st year graduate students, Tim Tiambeng, Samantha Knott, and Stephanie Werner have joined our group. Welcome!
  • Oct. 2016, Dr. Beini Lyu has joined our group as an honorary fellow. Welcome!
  • Oct. 2016, Prof. Ruixiang Liu, Dr. Fang Guo and Dr. Ya Liu have joined our group as visiting scholars. Welcome!
  • Anouncement: Professor Ying Ge and Professor Joe Loo (UCLA) are organizing a Uppcon2017 at Cornell. Check the conference website here! [ Uppcon 2017]
  • Aug. 2016, the Ge group enjoyed the summer's outing at the Devils Lake. [ Photos]
  • Jun. 2016, the Ge Group attended the 64th ASMS conference in San Antonio. [ Photos]
  • Apr. 2016, congratulations to Cyrus Colah on winning the Hilldale Undergraduate Fellowship! Thanks to Tania Guardado for being an excellent mentor!
  • Apr. 2016, Zach Gregorich is awarded with the 2016 ASMS (American Society for Mass Spectrometry) Graduate Student Award. Congratulations!
  • Mar. 2016, congratulations to our undergraduate student Rachel Heuer on receiving the Theodore Herfurth Sophomore Scholarship from the College of Letters and Science!
  • Jan. 2016, Yiwen Gu has joined the Ge Group. Welcome!

Most Recent Publications

  1. Gregorich Z. R.; Cai, W.; Jin, Y.; Wei, L.; Chen, A. J.; McKiernane, S. H.; Aiken, J. M.; Moss, R. L.; Diffee, G. M.; Ge, Y. Top-down targeted proteomics reveals decrease in myosin regulatory light chain phosphorylation that contributes to sarcopenic muscle dysfunction, J. Proteome Res., Epub ahead of Print. DOI: 10.1021/acs.jproteome.6b00244. (Ge, Y. Corresponding author)
  2. Crowe, S.O.; Pham, G.H.; Ziegler, J.C.; Deol, K.K.; Guenette, R.G.; Ge, Y.; Strieter, E.R. Subunit-specific labeling of ubiquitin chains by using sortase: insights into the selectivity of deubiquitinases. ChemBioChem., Epub ahead of print.
  3. Cai, W.; Tucholski, T. M.; Ge, Y. Top-down proteomics for comprehensive analysis of isoforms and post-translational modifications and its application to heart diseases. Expert Rev. Proteomics. (Ge, Y. Corresponding author)
  4. Jin, Y.; Peng, Y.; Lin, Z.; Chen, Y. C.; Wei, L.; Hacker, T. A.; Larsson, L.; Ge, Y. Comprehensive analysis of tropomyosin isoforms in skeletal muscles by top-down proteomics. J Muscle Res Cell Motil., 2016, 37(1-2):41-52. doi: 10.1007/s10974-016-9443-7. Epub 2016 Apr 18. (Ge, Y. Corresponding author)
  5. Hwang, L.; Guardado-Alvarez†, T.; Ayaz-Gunner, S.; Ge, Y.; Jin S. A Family of Photolabile Nitroveratryl-Based Surfactants That Self-Assemble into Photodegradable Supramolecular Structures. Langmuir, 2016, 32 (16): pp 3963–3969. (Ge, Y. Corresponding author)
  6. Chen, B.; Peng, Y.; Valeja, S. G.; Xiu, L.; Alpert, A. J.; Ge, Y. Online Hydrophobic Interaction Chromatography-Mass spectrometry for Top-down Proteomics. Anal. Chem. 2016, 88(3):1885-91. (Ge, Y. Corresponding author)
  7. Cai, W.; Guner, H.; Gregorich, Z. R.; Chen, A. J.; Ayaz-Guner, S.; Peng, Y.; Valeja, S. G.; Liu, X.; Ge, Y. MASH Suite Pro: A Comprehensive Software Tool for Top-down Proteomics. Mol. Cell. Proteomics. 2016, 15(2):703-14. (Ge, Y. Corresponding author)
  8. Yu, D.; Peng, Y.; Ayaz-Guner, S.; Gregorich Z. R.; Ge, Y. Comprehensive characterization of AMP-activated protein kinase catalytic domain by top-down mass spectrometry. J. Am. Soc. Mass Spectrom. 2016, 27(2): 220-232 (Ge, Y. Corresponding author)
  9. Gregorich Z. R.; Peng, Y.; Wolff, J. J.; Guo, W.; Guner, H.; Doop, J.; Hacker, T. A.; Ge, Y. Comprehensive assessment of regional and transmural heterogeneity in myofilament protein phosphorylation by top-down mass spectrometry. J. Mol. Cell. Cardiol. 2015, 87, 103-112. (Ge, Y. Corresponding author)
  10. Chen, Y.-C.; Ayaz-Guner, S.; Peng, Y.; Lane, M. L.; Locher, M.; Larsson, L.; Kohmoto, T.; Moss, R. L.; Ge, Y. A top-down LC/MS+ method for assessing actin isoforms as a potential cardiac disease marker. Anal Chem. 2015, 87(16): 8399-406. (Ge, Y. Corresponding author)
  11. Chang, Y. H.; Ye, L.; Cai, W.; Lee, Y.; Guner, H.; Lee, Y.; Kamp, T. J.; Zhang, J.; Ge, Y. Quantitative Proteomics Reveals Differential Regulation of Protein Expression in Recipient Myocardium after Trilineage Cardiovascular Cell Transplantation. Proteomics. 2015, 15, 2560-2567 doi: 10.1002/pmic.201500131. (Ge, Y. Corresponding author)
  12. Valeja, S. G.; Xiu, L.; Gregorich, Z. R.; Guner, H.; Jin, S.; Ge, Y. Three dimensional liquid chromatography coupling ion exchange chromatography/hydrophobic interaction chromatography/reverse phase chromatography for effective protein separation in top-down proteomics. Anal Chem. 2015, 87(10), 5363-71. (Ge, Y. Corresponding author)
  13. Hwang, L.; Ayaz-Guner, S.; Cai, W.; Gregorich Z. R.; Jin, S.; Ge, Y. Specific enrichment of phosphoproteins using functionalized multivalent nanoparticles. J. Am. Chem. Soc., 2015, 87, 5363-5371. (Ge, Y. Corresponding author)
  14. Chang, Y.; Gregorich Z. R.; Chen, A. J.; Hwang L.; Guner, H.; Yu, D.; Zhang, J.; Ge, Y. New mass spectrometry-compatible degradable surfactant for tissue proteomics. J. Proteome Res., 2015, 14, 1587-1599. (Ge, Y. Corresponding author)
  15. Chen, Y.; Sumandea, M. P.; Larsson, L.; Moss, R. L.; Ge, Y. Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry. J. Muscle Res. Cell Motil., 2015, 36, 168-181. (Ge, Y. Corresponding author)

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