Recent Publications

2022

Micek HM, Carroll MJ, Barroilhet L, Kreeger PK. Processing and Analysis of Ascites. Methods Mol Biol. 2022;2424:95-104. doi: 10.1007/978-1-0716-1956-8_5. PMID: 34918288.

Renner CM, Visetsouk MR, Kreeger PK, Masters KS. Multispectral Staining and Analysis of Extracellular Matrix. Methods Mol Biol. 2022;2424:105-119. doi: 10.1007/978-1-0716-1956-8_6. PMID: 34918289.

Brandt EB, Mahmoud AI. Quantifying Cardiomyocyte Proliferation and Nucleation to Assess Mammalian Cardiac Regeneration. Methods Mol Biol. 2022;2485:243-253. doi: 10.1007/978-1-0716-2261-2_16. PMID: 35618910.

Uenishi GI, Jung HS, Slukvin II. Assessment of Endothelial-to-Hematopoietic Transition of Individual Hemogenic Endothelium and Bulk Populations in Defined Conditions. Methods Mol Biol. 2022;2429:103-124. doi: 10.1007/978-1-0716-1979-7_8. PMID: 35507158.

Liao R, Bresnick EH. Heme as a differentiation-regulatory transcriptional cofactor. Int J Hematol. 2022 Aug;116(2):174-181. doi: 10.1007/s12185-022-03404-x. Epub 2022 Jul 1. PMID: 35776402.

Ash H, Chang A, Ortiz RJ, Kulkarni P, Rauch B, Colman R, Ferris CF, Ziegler TE. Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus). Behav Brain Res. 2022 Jul 26;430:113920. doi: 10.1016/j.bbr.2022.113920. Epub 2022 May 18. PMID: 35595058.

Weinfurter JT, D’Souza SS, Matschke LM, Bennett S, Kelnhofer-Millevolte LE, Suknuntha K, Kumar A, Coonen J, Capitini CM, Hematti P, Golos TG, Slukvin II, Reynolds MR. Allogeneic MHC-matched T-cell receptor α/β-depleted bone marrow transplants in SHIV-infected, ART-suppressed Mauritian cynomolgus macaques. Sci Rep. 2022 Jul 19;12(1):12345. doi: 10.1038/s41598-022-16306-z. PMID: 35853970.

Osorio-Méndez D, Miller A, Begeman IJ, Kurth A, Hagle R, Rolph D, Dickson AL, Chen CH, Halloran M, Poss KD, Kang J. Voltage-gated sodium channel scn8a is required for innervation and regeneration of amputated adult zebrafish fins. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2200342119. doi: 10.1073/pnas.2200342119. Epub 2022 Jul 6. PMID: 35867745.

Siahpirani AF, Knaack S, Chasman D, Seirup M, Sridharan R, Stewart R, Thomson J, Roy S. Dynamic regulatory module networks for inference of cell type-specific transcriptional networks. Genome Res. 2022 Jul;32(7):1367-1384. doi: 10.1101/gr.276542.121. Epub 2022 Jun 15. PMID: 35705328.

Anderson CL, Munawar S, Reilly L, Kamp TJ, January CT, Delisle BP, Eckhardt LL. How Functional Genomics Can Keep Pace With VUS Identification. Front Cardiovasc Med. 2022 Jul 4;9:900431. doi: 10.3389/fcvm.2022.900431. PMID: 35859585.

North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, Bewersdorf JP, Stanley RF, Erickson C, Cho H, Pineda JMB, Thomas JD, Polaski JT, Belleville AE, Gabel AM, Udy DB, Humbert O, Kiem HP, Abdel-Wahab O, Bradley RK. Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nat Biotechnol. 2022 Jul;40(7):1103-1113. doi: 10.1038/s41587-022-01224-2. Epub 2022 Mar 3. PMID: 35241838.

Larson EJ, Gregorich ZR, Zhang Y, Li BH, Aballo TJ, Melby JA, Ge Y, Guo W. Rbm20 ablation is associated with changes in the expression of titin-interacting and metabolic proteins. Mol Omics. 2022 Jun 28. doi: 10.1039/d2mo00115b. Epub ahead of print. PMID: 35762193.

Salamon RJ, Mahmoud AI. Bridging the communication gap: cardiomyocytes reciprocate sympathetic nerve signalling. J Physiol. 2022 Jun;600(12):2827-2828. doi: 10.1113/JP283173. Epub 2022 May 25. PMID: 35614020.

Zhang J, Gregorich ZR, Tao R, Kim GC, Lalit PA, Carvalho JL, Markandeya Y, Mosher DF, Palecek SP, Kamp TJ. Cardiac differentiation of human pluripotent stem cells using defined extracellular matrix proteins reveals essential role of fibronectin. Elife. 2022 Jun 27;11:e69028. doi: 10.7554/eLife.69028. PMID: 35758861.

Nicholson MW, Huang CY, Wang JY, Ting CY, Cheng YC, Chan DZH, Lee YC, Hsu CC, Hsu YH, Chang CMC, Hsieh ML, Cheng YY, Lin YL, Chen CH, Wu YT, Hacker TA, Wu JC, Kamp TJ, Hsieh PCH. Cardio- and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals (Basel). 2022 Jun 20;15(6):765. doi: 10.3390/ph15060765. PMID: 35745684.

Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. Ceramides are early responders in metabolic syndrome development in rhesus monkeys. Sci Rep. 2022 Jun 15;12(1):9960. doi: 10.1038/s41598-022-14083-3. PMID: 35705631.

Giffin-Rao Y, Sheng J, Strand B, Xu K, Huang L, Medo M, Risgaard KA, Dantinne S, Mohan S, Keshan A, Daley RA Jr, Levesque B, Amundson L, Reese R, Sousa AMM, Tao Y, Wang D, Zhang SC, Bhattacharyya A. Altered patterning of trisomy 21 interneuron progenitors. Stem Cell Reports. 2022 Jun 14;17(6):1366-1379. doi: 10.1016/j.stemcr.2022.05.001. Epub 2022 May 26. PMID: 35623352.

Apfelbaum AA, Wu F, Hawkins AG, Magnuson B, Jimenez JA, Taylor SD, Wrenn ED, Waltner O, Pfaltzgraff ER, Song JY, Hall C, Wellik DM, Ljungman M, Furlan SN, Ryan RJH, Sarthy JF, Lawlor ER. EWS-FLI1 and HOXD13 control tumor cell plasticity in Ewing sarcoma. Clin Cancer Res. 2022 Jun 2:clincanres.0384.2022-2-5 13:20:00.280. doi: 10.1158/1078-0432.CCR-22-0384. Epub ahead of print. PMID: 35653119.

Dukes NJ, Ash H, de Faria Oliveira G, Sosa ME, Goy RW, Colman RJ, Ziegler TE. Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus. Horm Behav. 2022 Jun;142:105162. doi: 10.1016/j.yhbeh.2022.105162. Epub 2022 Mar 30. PMID: 35366411.

Risgaard KA, Sorci IA, Mohan S, Bhattacharyya A. Meta-Analysis of Down Syndrome Cortical Development Reveals Underdeveloped State of the Science. Front Cell Neurosci. 2022 Jun 13;16:915272. doi: 10.3389/fncel.2022.915272. PMID: 35769326.

Wille CK, Sridharan R. Connecting the DOTs on Cell Identity. Front Cell Dev Biol. 2022 Jun 6;10:906713. doi: 10.3389/fcell.2022.906713. PMID: 35733849.

Buck KM, Roberts DS, Aballo TJ, Inman DR, Jin S, Ponik S, Brown KA, Ge Y. One-Pot Exosome Proteomics Enabled by a Photocleavable Surfactant. Anal Chem. 2022 May 24;94(20):7164-7168. doi: 10.1021/acs.analchem.2c01252. Epub 2022 May 11. PMID: 35543580.

Zhang S, Morgan X, Dogan B, Martin FP, Strickler S, Oka A, Herzog J, Liu B, Dowd SE, Huttenhower C, Pichaud M, Dogan EI, Satsangi J, Longman R, Yantiss R, Mueller LA, Scherl EJ, Sartor RB, Simpson KW. Mucosal metabolites fuel the growth and virulence of E. coli linked to Crohn’s disease. JCI Insight. 2022 May 23;7(10):e157013. doi: 10.1172/jci.insight.157013. PMID: 35413017.

Zhu Y, Esnault S, Ge Y, Jarjour NN, Brasier AR. Airway fibrin formation cascade in allergic asthma exacerbation: implications for inflammation and remodeling. Clin Proteomics. 2022 May 19;19(1):15. doi: 10.1186/s12014-022-09351-3. PMID: 35590254.

Stempien A, Josvai M, de Lange WJ, Hernandez JJ, Notbohm J, Kamp TJ, Valdivia HH, Eckhardt LL, Maginot KR, Ralphe JC, Crone WC. Identifying Features of Cardiac Disease Phenotypes Based on Mechanical Function in a Catecholaminergic Polymorphic Ventricular Tachycardia Model. Front Bioeng Biotechnol. 2022 May 10;10:873531. doi: 10.3389/fbioe.2022.873531. PMID: 35620470.

Zhang Y, Wang C, Sun M, Jin Y, Braz CU, Khatib H, Hacker TA, Liss M, Gotthardt M, Granzier H, Ge Y, Guo W. RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis. FASEB J. 2022 May;36(5):e22302. doi: 10.1096/fj.202101811RR. PMID: 35394688.

Kraynak M, Willging MM, Kuehlmann AL, Kapoor AA, Flowers MT, Colman RJ, Levine JE, Abbott DH. Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys. J Endocr Soc. 2022 Apr 22;6(6):bvac063. doi: 10.1210/jendso/bvac063. PMID: 35592515.

Zhu Y, Esnault S, Ge Y, Jarjour NN, Brasier AR. Segmental Bronchial Allergen Challenge Elicits Distinct Metabolic Phenotypes in Allergic Asthma. Metabolites. 2022 Apr 22;12(5):381. doi: 10.3390/metabo12050381. PMID: 35629885.

Goy RW, Shrestha HK, Colman RJ, Dukes NJ, Ziegler TE, Kapoor A. Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Apr 15;1195:123150. doi: 10.1016/j.jchromb.2022.123150. Epub 2022 Feb 25. PMID: 35247678.

Waters BJ, Blum B. Axon Guidance Molecules in the Islets of Langerhans. Front Endocrinol (Lausanne). 2022 Apr 14;13:869780. doi: 10.3389/fendo.2022.869780. PMID: 35498433.

D’Souza SS, Kumar A, Weinfurter J, Park MA, Maufort J, Tao L, Kang H, Dettle ST, Golos T, Thomson JA, Reynolds MR, Slukvin I. Generation of SIV-resistant T cells and macrophages from nonhuman primate induced pluripotent stem cells with edited CCR5 locus. Stem Cell Reports. 2022 Apr 12;17(4):953-963. doi: 10.1016/j.stemcr.2022.03.003. Epub 2022 Mar 31. PMID: 35364011.

D’Souza SS, Kumar A, Maufort J, Weinfurter JT, Raymond M, Strelchenko N, Perrin E, Coonen J, Mejia A, Simmons H, Torbett BE, Reynolds M, Thomson JA, Slukvin I. Assessment of Safety and Immunogenicity of MHC homozygous iPSC-derived CD34+ Hematopoietic Progenitors in a NHP Model. Blood Adv. 2022 Apr 11:bloodadvances.2022006984. doi: 10.1182/bloodadvances.2022006984. Epub ahead of print. PMID: 35404997.

Wu Y, West NR, Bhattacharyya A, Wiseman FK. Cell models for Down syndrome-Alzheimer’s disease research. Neuronal Signal. 2022 Apr 8;6(1):NS20210054. doi: 10.1042/NS20210054. PMID: 3544959.

Huang CY, Nicholson MW, Wang JY, Ting CY, Tsai MH, Cheng YC, Liu CL, Chan DZH, Lee YC, Hsu CC, Hsu YH, Yang CF, Chang CMC, Ruan SC, Lin PJ, Lin JH, Chen LL, Hsieh ML, Cheng YY, Hsu WT, Lin YL, Chen CH, Hsu YH, Wu YT, Hacker TA, Wu JC, Kamp TJ, Hsieh PCH. Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons. Cell Rep. 2022 Apr 5;39(1):110643. doi: 10.1016/j.celrep.2022.110643. PMID: 35385754.

Lynch AR, Arp NL, Zhou AS, Weaver BA, Burkard ME. Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference. Elife. 2022 Apr 5;11:e69799. doi: 10.7554/eLife.69799. PMID: 35380536.

Little CJ, Haynes WJ, Huang L, Daffada CM, Wolfe KB, Perrin E, Simpson JA, Kropp Schmidt JA, Hinkle HM, Keding LT, Behrens RT, Evans DT, Kaufman DB, Thomson JA, Golos TG, Brown ME. Robust engraftment of fetal nonhuman primate CD34-positive cells in immune-deficient mice. J Leukoc Biol. 2022 Mar 30. doi: 10.1002/JLB.5TA0921-481RR. Epub ahead of print. PMID: 35352381.

Balasubramanian P, Schaar AE, Gustafson GE, Smith AB, Howell PR, Greenman A, Baum S, Colman RJ, Lamming DW, Diffee GM, Anderson RM. Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice. Elife. 2022 Mar 17;11:e71282. doi: 10.7554/eLife.71282. PMID: 35297761.

Seirup M, Sengupta S, Swanson S, McIntosh BE, Collins M, Chu LF, Cheng Z, Gorkin DU, Duffin B, Bolin JM, Argus C, Stewart R, Thomson JA. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro. Genomics. 2022 Mar 9;114(3):110330. doi: 10.1016/j.ygeno.2022.110330. Epub ahead of print. PMID: 35278615.

Johnson KD, Soukup AA, Bresnick EH. GATA2 deficiency elevates interferon regulatory factor-8 to subvert a progenitor cell differentiation program. Blood Adv. 2022 Mar 8;6(5):1464-1473. doi: 10.1182/bloodadvances.2021006182. PMID: 35008108.

Tucholski T, Ge Y. Fourier-transform ion cyclotron resonance mass spectrometry for characterizing proteoforms. Mass Spectrom Rev. 2022 Mar;41(2):158-177. doi: 10.1002/mas.21653. Epub 2020 Sep 7. PMID: 32894796.

Murie M, Peng Y, Rigby MJ, Dieterich IA, Farrugia MA, Endresen A, Bhattacharyya A, Puglielli L. ATase inhibition rescues age-associated proteotoxicity of the secretory pathway. Commun Biol. 2022 Feb 25;5(1):173. doi: 10.1038/s42003-022-03118-0. PMID: 35217767.

You X, Zhou Y, Chang YI, Kong G, Ranheim EA, Johnson KD, Soukup AA, Bresnick EH, Zhang J. Gata2 +9.5 enhancer regulates adult hematopoietic stem cell self-renewal and T-cell development. Blood Adv. 2022 Feb 22;6(4):1095-1099. doi: 10.1182/bloodadvances.2021004311. PMID: 34516632.

Renner C, Gomez C, Visetsouk MR, Taha I, Khan A, McGregor SM, Weisman P, Naba A, Masters KS, Kreeger PK. Multi-modal Profiling of the Extracellular Matrix of Human Fallopian Tubes and Serous Tubal Intraepithelial Carcinomas. J Histochem Cytochem. 2022 Feb;70(2):151-168. doi: 10.1369/00221554211061359. Epub 2021 Dec 5. PMID: 34866441.

Fertal SA, Poterala JE, Ponik SM, Wisinski KB. Stromal Characteristics and Impact on New Therapies for Metastatic Triple-Negative Breast Cancer. Cancers (Basel). 2022 Feb 27;14(5):1238. doi: 10.3390/cancers14051238. PMID: 35267548; PMCID.

Wille CK, Sridharan R. DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome. Stem Cell Reports. 2022 Feb 8;17(2):384-396. doi: 10.1016/j.stemcr.2021.12.004. Epub 2022 Jan 6. PMID: 34995500.

Li Q, Jiang B, Guo J, Shao H, Del Priore IS, Chang Q, Kudo R, Li Z, Razavi P, Liu B, Boghossian AS, Rees MG, Ronan MM, Roth JA, Donovan KA, Palafox M, Reis-Filho JS, de Stanchina E, Fischer ES, Rosen N, Serra V, Koff A, Chodera JD, Gray NS, Chandarlapaty S. INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors. Cancer Discov. 2022 Feb;12(2):356-371. doi: 10.1158/2159-8290.CD-20-1726. Epub 2021 Sep 20. PMID: 34544752.

Peng X, Lai KS, She P, Kang J, Wang T, Li G, Zhou Y, Sun J, Jin D, Xu X, Liao L, Liu J, Lee E, Poss KD, Zhong TP. Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration. J Mol Cell Biol. 2021 Apr 10;13(1):41-58. doi: 10.1093/jmcb/mjaa046. Erratum in: J Mol Cell Biol. 2022 Jan 29;13(12):921. PMID: 33582796.

Lo Sardo V, Kamp TJ. Preventing Anthracycline-Induced Cardiotoxicity Using Functional Genomics and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circulation. 2022 Jan 25;145(4):295-298. doi: 10.1161/CIRCULATIONAHA.121.058128. Epub 2022 Jan 24. PMID: 35073175.

Bacher R, Chu LF, Argus C, Bolin JM, Knight P, Thomson JA, Stewart R, Kendziorski C. Enhancing biological signals and detection rates in single-cell RNA-seq experiments with cDNA library equalization. Nucleic Acids Res. 2022 Jan 25;50(2):e12. doi: 10.1093/nar/gkab1071. PMID: 34850101.

Li A, Campbell K, Lal S, Ge Y, Keogh A, Macdonald PS, Lau P, Lai J, Linke WA, Van der Velden J, Field A, Martinac B, Grosser M, Dos Remedios C. Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease. Biophys Rev. 2022 Jan 24;14(1):369-379. doi: 10.1007/s12551-022-00930-0. PMID: 35340597.

Schiavo RK, Tamplin OJ. Vascular endothelial growth factor c regulates hematopoietic stem cell fate in the dorsal aorta. Development. 2022 Jan 15;149(2):dev199498. doi: 10.1242/dev.199498. Epub 2022 Jan 18. PMID: 34919128.

Fathi A, Mathivanan S, Kong L, Petersen AJ, Harder CRK, Block J, Miller JM, Bhattacharyya A, Wang D, Zhang SC. Chemically induced senescence in human stem cell-derived neurons promotes phenotypic presentation of neurodegeneration. Aging Cell. 2022 Jan;21(1):e13541. doi: 10.1111/acel.13541. Epub 2021 Dec 24. PMID: 34953016.

Cosper PF, Copeland SE, Tucker JB, Weaver BA. Chromosome Missegregation as a Modulator of Radiation Sensitivity. Semin Radiat Oncol. 2022 Jan;32(1):54-63. doi: 10.1016/j.semradonc.2021.09.002. PMID: 34861996.

2021

Hunt JFV, Li M, Risgaard R, Ananiev GE, Wildman S, Zhang F, Bugni TS, Zhao X, Bhattacharyya A. High Throughput Small Molecule Screen for Reactivation of FMR1 in Fragile X Syndrome Human Neural Cells. Cells. 2021 Dec 27;11(1):69. doi: 10.3390/cells11010069. PMID: 35011630.

Hu Y, Manasrah BK, McGregor SM, Lera RF, Norman RX, Tucker JB, Scribano CM, Yan RE, Humayun M, Wisinski KB, Tevaarwerk AJ, O’Regan RM, Wilke LG, Weaver BA, Beebe DJ, Jin N, Burkard ME. Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS-STING Signaling in Triple-Negative Breast Cancer. Mol Cancer Ther. 2021 Dec;20(12):2553-2567. doi: 10.1158/1535-7163.MCT-21-0195. Epub 2021 Sep 28. PMID: 34583980.

Bliss-Moreau E, Amara RR, Buffalo EA, Colman RJ, Embers ME, Morrison JH, Quillen EE, Sacha JB, Roberts CT; National Primate Research Center Consortium Rigor and Reproducibility Working Group. Improving rigor and reproducibility in nonhuman primate research. Am J Primatol. 2021 Dec;83(12):e23331. doi: 10.1002/ajp.23331. Epub 2021 Sep 20. PMID: 34541703.

Lu S, Conn DJ, Chen S, Johnson KD, Bresnick EH, Keleş S. MLG: multilayer graph clustering for multi-condition scRNA-seq data. Nucleic Acids Res. 2021 Dec 16;49(22):e127. doi: 10.1093/nar/gkab823. PMID: 34581807.

Soukup A, Matson DR, Liu P, Johnson KD, Bresnick EH. Conditionally pathogenic genetic variants of a hematopoietic disease-suppressing enhancer. Sci Adv. 2021 Dec 10;7(50):eabk3521. doi: 10.1126/sciadv.abk3521. Epub 2021 Dec 10. PMID: 34890222.

Anderson CL, Langer ER, Routes TC, McWilliams SF, Bereslavskyy I, Kamp TJ, Eckhardt LL. Most myopathic lamin variants aggregate: a functional genomics approach for assessing variants of uncertain significance. NPJ Genom Med. 2021 Dec 3;6(1):103. doi: 10.1038/s41525-021-00265-x. PMID: 34862408.

Li MH, Marty-Santos LM, van Ginkel PR, McDermott AE, Rasky AJ, Lukacs NW, Wellik DM. The Lung Elastin Matrix Undergoes Rapid Degradation Upon Adult Loss of Hox5 Function. Front Cell Dev Biol. 2021 Nov 26;9:767454. doi: 10.3389/fcell.2021.767454. PMID: 34901011.

Tamplin OJ. Dopamine motivates stem cells for reward. Blood. 2021 Nov 25;138(21):2012-2014. doi: 10.1182/blood.2021013538. PMID: 34821941.

Proestaki M, Burkel BM, Galles EE, Ponik SM, Notbohm J. Effect of matrix heterogeneity on cell mechanosensing. Soft Matter. 2021 Nov 24;17(45):10263-10273. doi: 10.1039/d1sm00312g. PMID: 34125129.

Zhang J, Bolli R, Garry DJ, Marbán E, Menasché P, Zimmermann WH, Kamp TJ, Wu JC, Dzau VJ. Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 Nov 23;78(21):2092-2105. doi: 10.1016/j.jacc.2021.09.019. PMID: 34794691.

Tiambeng TN, Wu Z, Melby JA, Ge Y. Size Exclusion Chromatography Strategies and MASH Explorer for Large Proteoform Characterization. Methods Mol Biol. 2022;2500:15-30. doi: 10.1007/978-1-0716-2325-1_3. PMID: 35657584.

Smith LM, Agar JN, Chamot-Rooke J, Danis PO, Ge Y, Loo JA, Paša-Tolić L, Tsybin YO, Kelleher NL; Consortium for Top-Down Proteomics. The Human Proteoform Project: Defining the human proteome. Sci Adv. 2021 Nov 12;7(46):eabk0734. doi: 10.1126/sciadv.abk0734. Epub 2021 Nov 12. PMID: 34767442.

Brown KA, Anderson C, Reilly L, Sondhi K, Ge Y, Eckhardt LL. Proteomic Analysis of the Functional Inward Rectifier Potassium Channel (Kir) 2.1 Reveals Several Novel Phosphorylation Sites. Biochemistry. 2021 Nov 9;60(44):3292-3301. doi: 10.1021/acs.biochem.1c00555. Epub 2021 Oct 22. PMID: 34676745.

Krause HB, Bondarowicz H, Karls AL, McClean MN, Kreeger PK. Design and implementation of a microfluidic device capable of temporal growth factor delivery reveal filtering capabilities of the EGFR/ERK pathway. APL Bioeng. 2021 Nov 2;5(4):046101. doi: 10.1063/5.0059011. PMID: 34765858.

Palliyaguru DL, Shiroma EJ, Nam JK, Duregon E, Vieira Ligo Teixeira C, Price NL, Bernier M, Camandola S, Vaughan KL, Colman RJ, Deighan A, Korstanje R, Peters LL, Dickinson SL, Ejima K, Simonsick EM, Launer LJ, Chia CW, Egan J, Allison DB, Churchill GA, Anderson RM, Ferrucci L, Mattison JA, de Cabo R. Fasting blood glucose as a predictor of mortality: Lost in translation. Cell Metab. 2021 Nov 2;33(11):2189-2200.e3. doi: 10.1016/j.cmet.2021.08.013. Epub 2021 Sep 10. PMID: 34508697

Napiwocki BN, Stempien A, Lang D, Kruepke RA, Kim G, Zhang J, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC. Micropattern platform promotes extracellular matrix remodeling by human PSC-derived cardiac fibroblasts and enhances contractility of co-cultured cardiomyocytes. Physiol Rep. 2021 Oct;9(19):e15045. doi: 10.14814/phy2.15045. PMID: 34617673; PMCID: PMC8496154.

Crocker KL, Ahern-Djamali S, Boekhoff-Falk G. Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain. J Vis Exp. 2021 Oct 8;(176). doi: 10.3791/63182. PMID: 34694294.

Crocker KL, Marischuk K, Rimkus SA, Zhou H, Yin JCP, Boekhoff-Falk G. Neurogenesis in the adult Drosophila brain. Genetics. 2021 Oct 2;219(2):iyab092. doi: 10.1093/genetics/iyab092. PMID: 34117750.

Tampakakis E, Mahmoud AI. The role of hormones and neurons in cardiomyocyte maturation. Semin Cell Dev Biol. 2021 Oct;118:136-143. doi: 10.1016/j.semcdb.2021.03.026. Epub 2021 Apr 28. PMID: 33931308.

Bayne EF, Simmons AD, Roberts DS, Zhu Y, Aballo TJ, Wancewicz B, Palecek SP, Ge Y. Multiomics Method Enabled by Sequential Metabolomics and Proteomics for Human Pluripotent Stem-Cell-Derived Cardiomyocytes. J Proteome Res. 2021 Oct 1;20(10):4646-4654. doi: 10.1021/acs.jproteome.1c00611. Epub 2021 Sep 9. PMID: 34499502.

Mehta C, Fraga de Andrade I, Matson DR, Dewey CN, Bresnick EH. RNA-regulatory exosome complex confers cellular survival to promote erythropoiesis. Nucleic Acids Res. 2021 Sep 20;49(16):9007-9025. doi: 10.1093/nar/gkab367. PMID: 34059908.

Scribano CM, Wan J, Esbona K, Tucker JB, Lasek A, Zhou AS, Zasadil LM, Molini R, Fitzgerald J, Lager AM, Laffin JJ, Correia-Staudt K, Wisinski KB, Tevaarwerk AJ, O’Regan R, McGregor SM, Fowler AM, Chappell RJ, Bugni TS, Burkard ME, Weaver BA. Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel. Sci Transl Med. 2021 Sep 8;13(610):eabd4811. doi: 10.1126/scitranslmed.abd4811. Epub 2021 Sep 8. PMID: 34516829.

Nimkulrat SD, Bernstein MN, Ni Z, Brown J, Kendziorski C, Blum B. The Anna Karenina Model of β-Cell Maturation in Development and Their Dedifferentiation in Type 1 and Type 2 Diabetes. Diabetes. 2021 Sep;70(9):2058-2066. doi: 10.2337/db21-0211. Epub 2021 Jun 15. PMID: 34417264.

Floy ME, Givens SE, Matthys OB, Mateyka TD, Kerr CM, Steinberg AB, Silva AC, Zhang J, Mei Y, Ogle BM, McDevitt TC, Kamp TJ, Palecek SP. Developmental lineage of human pluripotent stem cell-derived cardiac fibroblasts affects their functional phenotype. FASEB J. 2021 Sep;35(9):e21799. doi: 10.1096/fj.202100523R. PMID: 34339055.

Keen KL, Petersen AJ, Figueroa AG, Fordyce BI, Shin J, Yadav R, Erdin S, Pearce RA, Talkowski ME, Bhattacharyya A, Terasawa E. Physiological Characterization and Transcriptomic Properties of GnRH Neurons Derived From Human Stem Cells. Endocrinology. 2021 Sep 1;162(9):bqab120. doi: 10.1210/endocr/bqab120. PMID: 34125902.

Roberts DS, Mann M, Melby JA, Larson EJ, Zhu Y, Brasier AR, Jin S, Ge Y. Structural O-Glycoform Heterogeneity of the SARS-CoV-2 Spike Protein Receptor-Binding Domain Revealed by Top-Down Mass Spectrometry. J Am Chem Soc. 2021 Aug 11;143(31):12014-12024. doi: 10.1021/jacs.1c02713. Epub 2021 Jul 30. PMID: 34328324.

Zhang J, Yang N, Kreeger PK, Notbohm J. Topological defects in the mesothelium suppress ovarian cancer cell clearance. APL Bioeng. 2021 Aug 3;5(3):036103. doi: 10.1063/5.0047523. PMID: 34396026.

Aballo TJ, Roberts DS, Melby JA, Buck KM, Brown KA, Ge Y. Ultrafast and Reproducible Proteomics from Small Amounts of Heart Tissue Enabled by Azo and timsTOF Pro. J Proteome Res. 2021 Aug 6;20(8):4203-4211. doi: 10.1021/acs.jproteome.1c00446. Epub 2021 Jul 8. PMID: 34236868.

Kellie JF, Tran JC, Jian W, Jones B, Mehl JT, Ge Y, Henion J, Bateman KP. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective. J Am Soc Mass Spectrom. 2021 Aug 4;32(8):1886-1900. doi: 10.1021/jasms.0c00270. Epub 2020 Sep 15. PMID: 32869982.

Larson EJ, Roberts DS, Melby JA, Buck KM, Zhu Y, Zhou S, Han L, Zhang Q, Ge Y. High-Throughput Multi-attribute Analysis of Antibody-Drug Conjugates Enabled by Trapped Ion Mobility Spectrometry and Top-Down Mass Spectrometry. Anal Chem. 2021 Jul 27;93(29):10013-10021. doi: 10.1021/acs.analchem.1c00150. Epub 2021 Jul 14. PMID: 34258999.

Teng EL, Masutani EM, Yeoman B, Fung J, Lian R, Ngo B, Kumar A, Placone JK, Lo Sardo V, Engler AJ. High shear stress enhances endothelial permeability in the presence of the risk haplotype at 9p21.3. APL Bioeng. 2021 Jul 26;5(3):036102. doi: 10.1063/5.0054639. PMID: 34327295.

Bae J, Paltzer WG, Mahmoud AI. The Role of Metabolism in Heart Failure and Regeneration. Front Cardiovasc Med. 2021 Jul 16;8:702920. doi: 10.3389/fcvm.2021.702920. PMID: 34336958.

Martinez JL, Zammit MD, West NR, Christian BT, Bhattacharyya A. Basal Forebrain Cholinergic Neurons: Linking Down Syndrome and Alzheimer’s Disease. Front Aging Neurosci. 2021 Jul 12;13:703876. doi: 10.3389/fnagi.2021.703876. Erratum in: Front Aging Neurosci. 2021 Aug 05;13:742233. PMID: 34322015.

Adams MT, Dwulet JM, Briggs JK, Reissaus CA, Jin E, Szulczewski JM, Lyman MR, Sdao SM, Kravets V, Nimkulrat SD, Ponik SM, Merrins MJ, Mirmira RG, Linnemann AK, Benninger RK, Blum B. Reduced synchroneity of intra-islet Ca2+ oscillations in vivo in Robo-deficient β cells. Elife. 2021 Jul 7;10:e61308. doi: 10.7554/eLife.61308. PMID: 34231467.

Dierssen M, Herault Y, Helguera P, Martínez de Lagran M, Vazquez A, Christian B, Carmona-Iragui M, Wiseman F, Mobley W, Fisher EMC, Brault V, Esbensen A, Jacola LM, Potier MC, Hamlett ED, Abbeduto L, Del Hoyo Soriano L, Busciglio J, Iulita MF, Crispino J, Malinge S, Barone E, Perluigi M, Costanzo F, Delabar JM, Bartesaghi R, Dekker AD, De Deyn P, Fortea Ormaechea J, Shaw PA, Haydar TF, Sherman SL, Strydom A, Bhattacharyya A. Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society. Mol Syndromol. 2021 Jul;12(4):202-218. doi: 10.1159/000514437. Epub 2021 May 20. PMID: 34421499.

Souder DC, Dreischmeier IA, Smith AB, Wright S, Martin SA, Sagar MAK, Eliceiri KW, Salamat SM, Bendlin BB, Colman RJ, Beasley TM, Anderson RM. Rhesus monkeys as a translational model for late-onset Alzheimer’s disease. Aging Cell. 2021 Jun;20(6):e13374. doi: 10.1111/acel.13374. Epub 2021 May 5. PMID: 33951283.

Truchan NA, Fenske RJ, Sandhu HK, Weeks AM, Patibandla C, Wancewicz B, Pabich S, Reuter A, Harrington JM, Brill AL, Peter DC, Nall R, Daniels M, Punt M, Kaiser CE, Cox ED, Ge Y, Davis DB, Kimple ME. Human Islet Expression Levels of Prostaglandin E2 Synthetic Enzymes, But Not Prostaglandin EP3 Receptor, Are Positively Correlated with Markers of β-Cell Function and Mass in Nondiabetic Obesity. ACS Pharmacol Transl Sci. 2021 Jun 16;4(4):1338-1348. doi: 10.1021/acsptsci.1c00045. PMID: 34423270.

Goodroe A, Wachtman L, Benedict W, Allen-Worthington K, Bakker J, Burns M, Diaz LL, Dick E, Dickerson M, Eliades SJ, Gonzalez O, Graf DJ, Haroush K, Inoue T, Izzi J, Laudano A, Layne-Colon D, Leblanc M, Ludwig B, Mejia A, Miller C, Sarfaty A, Sosa M, Vallender E, Brown C, Forney L, Schultz-Darken N, Colman R, Power M, Capuano S, Ross C, Tardif S. Current practices in nutrition management and disease incidence of common marmosets (Callithrix jacchus). J Med Primatol. 2021 Jun;50(3):164-175. doi: 10.1111/jmp.12525. Epub 2021 Apr 28. PMID: 33913156.

Tang XY, Xu L, Wang J, Hong Y, Wang Y, Zhu Q, Wang D, Zhang XY, Liu CY, Fang KH, Han X, Wang S, Wang X, Xu M, Bhattacharyya A, Guo X, Lin M, Liu Y. DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome. J Clin Invest. 2021 Jun 15;131(12):e135763. doi: 10.1172/JCI135763. PMID: 33945512.

Anderson NC, Chen PF, Meganathan K, Afshar Saber W, Petersen AJ, Bhattacharyya A, Kroll KL, Sahin M; Cross-IDDRC Human Stem Cell Working Group. Balancing serendipity and reproducibility: Pluripotent stem cells as experimental systems for intellectual and developmental disorders. Stem Cell Reports. 2021 Jun 8;16(6):1446-1457. doi: 10.1016/j.stemcr.2021.03.025. Epub 2021 Apr 15. PMID: 33861989.

Singh P, Banerjee R, Piao S, Costa de Medeiros M, Bellile E, Liu M, Damodaran Puthiya Veettil D, Schmitd LB, Russo N, Danella E, Inglehart RC, Pineault KM, Wellik DM, Wolf G, D’Silva NJ. Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion. J Exp Med. 2021 Jun 7;218(6):e20200944. doi: 10.1084/jem.20200944. PMID: 33835136.

Melby JA, Roberts DS, Larson EJ, Brown KA, Bayne EF, Jin S, Ge Y. Novel Strategies to Address the Challenges in Top-Down Proteomics. J Am Soc Mass Spectrom. 2021 Jun 2;32(6):1278-1294. doi: 10.1021/jasms.1c00099. Epub 2021 May 13. PMID: 33983025.

Hendrix JA, Amon A, Abbeduto L, Agiovlasitis S, Alsaied T, Anderson HA, Bain LJ, Baumer N, Bhattacharyya A, Bogunovic D, Botteron KN, Capone G, Chandan P, Chase I, Chicoine B, Cieuta-Walti C, DeRuisseau LR, Durand S, Esbensen A, Fortea J, Giménez S, Granholm AC, Hahn LJ, Head E, Hillerstrom H, Jacola LM, Janicki MP, Jasien JM, Kamer AR, Kent RD, Khor B, Lawrence JB, Lemonnier C, Lewanda AF, Mobley W, Moore PE, Nelson LP, Oreskovic NM, Osorio RS, Patterson D, Rasmussen SA, Reeves RH, Roizen N, Santoro S, Sherman SL, Talib N, Tapia IE, Walsh KM, Warren SF, White AN, Wong GW, Yi JS. Opportunities, barriers, and recommendations in down syndrome research. Transl Sci Rare Dis. 2021;5(3-4):99-129. doi: 10.3233/trd-200090. Epub 2021 Apr 15. PMID: 34268067.

Bae J, Salamon RJ, Brandt EB, Paltzer WG, Zhang Z, Britt EC, Hacker TA, Fan J, Mahmoud AI. Malonate Promotes Adult Cardiomyocyte Proliferation and Heart Regeneration. Circulation. 2021 May 18;143(20):1973-1986. doi: 10.1161/CIRCULATIONAHA.120.049952. Epub 2021 Mar 5. PMID: 33666092.

Manian KV, Galloway CA, Dalvi S, Emanuel AA, Mereness JA, Black W, Winschel L, Soto C, Li Y, Song Y, DeMaria W, Kumar A, Slukvin I, Schwartz MP, Murphy WL, Anand-Apte B, Chung M, Benoit DSW, Singh R. 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration. Cell Stem Cell. 2021 May 6;28(5):846-862.e8. doi: 10.1016/j.stem.2021.02.006. Epub 2021 Mar 29. Erratum in: Cell Stem Cell. 2021 May 6;28(5):978. PMID: 33784497.

Chiang CW, Shu WC, Wan J, Weaver BA, Jackson MB. Recordings from neuron-HEK cell cocultures reveal the determinants of miniature excitatory postsynaptic currents. J Gen Physiol. 2021 May 3;153(5):e202012849. doi: 10.1085/jgp.202012849. PMID: 33755721.

Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 May;53(5):707-718. doi: 10.1038/s41588-021-00828-9. Epub 2021 Apr 12. PMID: 33846634.

Macdonald EB, Begovatz P, Barton GP, Erickson-Bhatt S, Inman DR, Cox BL, Eliceiri KW, Strigel RM, Ponik SM, Fain SB. Hyperpolarized 13C Magnetic Resonance Spectroscopic Imaging of Pyruvate Metabolism in Murine Breast Cancer Models of Different Metastatic Potential. Metabolites. 2021 Apr 27;11(5):274. doi: 10.3390/metabo11050274. PMID: 33925445.

Huang SS, Lee KJ, Chen HC, Prajnamitra RP, Hsu CH, Jian CB, Yu XE, Chueh DY, Kuo CW, Chiang TC, Choong OK, Huang SC, Beh CY, Chen LL, Lai JJ, Chen P, Kamp TJ, Tien YW, Lee HM, Hsieh PC. Immune cell shuttle for precise delivery of nanotherapeutics for heart disease and cancer. Sci Adv. 2021 Apr 23;7(17):eabf2400. doi: 10.1126/sciadv.abf2400. PMID: 33893103.

Pretorius D, Kahn-Krell AM, Lou X, Fast VG, Berry JL, Kamp TJ, Zhang J. Layer-By-Layer Fabrication of Large and Thick Human Cardiac Muscle Patch Constructs With Superior Electrophysiological Properties. Front Cell Dev Biol. 2021 Apr 16;9:670504. doi: 10.3389/fcell.2021.670504. PMID: 33937272.

Zheng Q, Ozbudak E, Liu G, Hosmani PS, Saha S, Flores-Gonzalez M, Mueller LA, Rodrigues-Stuart K, Dewdney MM, Lin Y, Zhang J, Tarazona YC, Liu B, Oliva R, Ritenour MA, Cano LM. Draft Genome Sequence Resource of the Citrus Stem-End Rot Fungal Pathogen Lasiodiplodia theobromae CITRA15. Phytopathology. 2021 Apr;111(4):761-764. doi: 10.1094/PHYTO-08-20-0349-A. Epub 2021 Mar 8. PMID: 33190608.

Feng L, Zhang J, Lee C, Kim G, Liu F, Petersen AJ, Lim E, Anderson CL, Orland KM, Robertson GA, Eckhardt LL, January CT, Kamp TJ. Long QT Syndrome KCNH2 Variant Induces hERG1a/1b Subunit Imbalance in Patient-Specific Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Circ Arrhythm Electrophysiol. 2021 Apr;14(4):e009343. doi: 10.1161/CIRCEP.120.009343. Epub 2021 Mar 17. PMID: 33729832.

Mann M, Roberts DS, Zhu Y, Li Y, Zhou J, Ge Y, Brasier AR. Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation-Serial Fragmentation (PASEF) Mass Spectrometry. Viruses. 2021 Mar 11;13(3):454. doi: 10.3390/v13030454. PMID: 33799525.

Tong J, Sun T, Ma S, Zhao Y, Ju M, Gao Y, Zhu P, Tan P, Fu R, Zhang A, Wang D, Wang D, Xiao Z, Zhou J, Yang R, Loughran SJ, Li J, Green AR, Bresnick EH, Wang D, Cheng T, Zhang L, Shi L. Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms. Cell Stem Cell. 2021 Mar 4;28(3):502-513.e6. doi: 10.1016/j.stem.2021.01.018. Epub 2021 Feb 22. Erratum in: Cell Stem Cell. 2021 Apr 1;28(4):780. PMID: 33621485.

Humayun M, Ayuso JM, Brenneke RA, Virumbrales-Muñoz M, Lugo-Cintrón K, Kerr S, Ponik SM, Beebe DJ. Elucidating cancer-vascular paracrine signaling using a human organotypic breast cancer cell extravasation model. Biomaterials. 2021 Mar;270:120640. doi: 10.1016/j.biomaterials.2020.120640. Epub 2021 Feb 6. PMID: 33592387.

You X, Chang YI, Kong G, Ranheim EA, Zhou Y, Johnson KD, Mehta C, Bresnick EH, Zhang J. Gata2 -77 enhancer regulates adult hematopoietic stem cell survival. Leukemia. 2021 Mar;35(3):901-905. doi: 10.1038/s41375-020-0942-6. Epub 2020 Jun 27. PMID: 32594099.

Pagani CA, Huber AK, Hwang C, Marini S, Padmanabhan K, Livingston N, Nunez J, Sun Y, Edwards N, Cheng YH, Visser N, Yu P, Patel N, Greenstein JA, Rasheed H, Nelson R, Kessel K, Vasquez K, Strong AL, Hespe GE, Song JY, Wellik DM, Levi B. Novel Lineage-Tracing System to Identify Site-Specific Ectopic Bone Precursor Cells. Stem Cell Reports. 2021 Mar 9;16(3):626-640. doi: 10.1016/j.stemcr.2021.01.011. Epub 2021 Feb 18. PMID: 33606989.

Brown J, Barry C, Schmitz MT, Argus C, Bolin JM, Schwartz MP, Van Aartsen A, Steill J, Swanson S, Stewart R, Thomson JA, Kendziorski C. Interspecies chimeric conditions affect the developmental rate of human pluripotent stem cells. PLoS Comput Biol. 2021 Mar 1;17(3):e1008778. doi: 10.1371/journal.pcbi.1008778. PMID: 33647016.

Matson DR, Denu RA, Zasadil LM, Burkard ME, Weaver BA, Flynn C, Stukenberg PT. High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability. BMC Cancer. 2021 Feb 23;21(1):186. doi: 10.1186/s12885-021-07893-7. PMID: 33622270.

Jung HS, Uenishi G, Park MA, Liu P, Suknuntha K, Raymond M, Choi YJ, Thomson JA, Ong IM, Slukvin II. SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis. Cell Rep. 2021 Feb 16;34(7):108758. doi: 10.1016/j.celrep.2021.108758. PMID: 33596423.

Shao L, Elujoba-Bridenstine A, Zink KE, Sanchez LM, Cox BJ, Pollok KE, Sinn AL, Bailey BJ, Sims EC, Cooper SH, Broxmeyer HE, Pajcini KV, Tamplin OJ. The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood. 2021 Feb 11;137(6):775-787. doi: 10.1182/blood.2019004415. PMID: 32881992.

You X, Ryu MJ, Cho E, Sang Y, Damnernsawad A, Zhou Y, Liu Y, Zhang J, Lee Y. Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects. Front Cell Dev Biol. 2021 Feb 11;9:633661. doi: 10.3389/fcell.2021.633661. PMID: 33681212.

Melby JA, de Lange WJ, Zhang J, Roberts DS, Mitchell SD, Tucholski T, Kim G, Kyrvasilis A, McIlwain SJ, Kamp TJ, Ralphe JC, Ge Y. Functionally Integrated Top-Down Proteomics for Standardized Assessment of Human Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues. J Proteome Res. 2021 Feb 5;20(2):1424-1433. doi: 10.1021/acs.jproteome.0c00830. Epub 2021 Jan 4. PMID: 33395532.

Li Y, Wang D, Wang H, Huang X, Wen Y, Wang B, Xu C, Gao J, Liu J, Tong J, Wang M, Su P, Ren S, Ma F, Li HD, Bresnick EH, Zhou J, Shi L. A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells. EMBO Rep. 2021 Jan 7;22(1):e50535. doi: 10.15252/embr.202050535. Epub 2020 Dec 15. PMID: 33319461.

Cavalcante de Andrade Silva M, Katsumura KR, Mehta C, Velloso EDRP, Bresnick EH, Godley LA. Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome. Leukemia. 2021 Jan;35(1):264-268. doi: 10.1038/s41375-020-0820-2. Epub 2020 Apr 14. PMID: 32286542.

Schaid MD, Zhu Y, Richardson NE, Patibandla C, Ong IM, Fenske RJ, Neuman JC, Guthery E, Reuter A, Sandhu HK, Fuller MH, Cox ED, Davis DB, Layden BT, Brasier AR, Lamming DW, Ge Y, Kimple ME. Systemic Metabolic Alterations Correlate with Islet-Level Prostaglandin E2 Production and Signaling Mechanisms That Predict β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes. Metabolites. 2021 Jan 16;11(1):58. doi: 10.3390/metabo11010058. PMID: 33467110.

Tamplin OJ. Remodel your way to fetal hematopoiesis. Blood. 2021 Jan 14;137(2):146-148. doi: 10.1182/blood.2020008380. PMID: 33443560.

Liu B, Liu Z, Chen S, Ki M, Erickson C, Reis-Filho JS, Durham BH, Chang Q, de Stanchina E, Sun Y, Rabadan R, Abdel-Wahab O, Chandarlapaty S. Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis. J Clin Invest. 2021 Jan 4;131(1):e138315. doi: 10.1172/JCI138315. PMID: 33031100.

Napiwocki BN, Lang D, Stempien A, Zhang J, Vaidyanathan R, Makielski JC, Eckhardt LL, Glukhov AV, Kamp TJ, Crone WC. Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts. Biotechnol Bioeng. 2021 Jan;118(1):442-452. doi: 10.1002/bit.27582. Epub 2020 Oct 13. PMID: 32990953.

D’Souza SS, Bennett S, Kumar A, Kelnhofer LE, Weinfurter J, Suknuntha K, Coonen J, Mejia A, Simmons H, Golos T, Hematti P, Capitini CM, Reynolds MR, Slukvin II. Transplantation of T-cell receptor α/β-depleted allogeneic bone marrow in nonhuman primates. Exp Hematol. 2021 Jan;93:44-51. doi: 10.1016/j.exphem.2020.09.198. Epub 2020 Nov 8. PMID: 33176119.

Funk LC, Wan J, Ryan SD, Kaur C, Sullivan R, Roopra A, Weaver BA. p53 Is Not Required for High CIN to Induce Tumor Suppression. Mol Cancer Res. 2021 Jan;19(1):112-123. doi: 10.1158/1541-7786.MCR-20-0488. Epub 2020 Sep 18. PMID: 32948674.

2020

Liu P, Soukup AA, Bresnick EH, Dewey CN, Keles S. PRAM: a novel pooling approach for discovering intergenic transcripts from large-scale RNA sequencing experiments. Genome Res. 2020 Sep 21:gr.252445.119. doi: 10.1101/gr.252445.119. Epub ahead of print. PubMed PMID: 32958497.

Kellie JF, Tran JC, Jian W, Jones B, Mehl JT, Ge Y, Henion J, Bateman KP. Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective. J Am Soc Mass Spectrom. 2020 Sep 15. doi: 10.1021/jasms.0c00270. Epub ahead of print. PubMed PMID: 32869982.

Tucholski T, Ge Y. Fourier-transform ion cyclotron resonance mass spectrometry for characterizing proteoforms. Mass Spectrom Rev. 2020 Sep 7. doi: 10.1002/mas.21653. Epub ahead of print. PubMed PMID: 32894796.

Wu Z, Roberts DS, Melby JA, Wenger K, Wetzel M, Gu Y, Ramanathan SG, Bayne EF, Liu X, Sun R, Ong IM, McIlwain SJ, Ge Y. MASH Explorer: A Universal Software Environment for Top-Down Proteomics. J Proteome Res. 2020 Sep 4;19(9):3867-3876. doi: 10.1021/acs.jproteome.0c00469. Epub 2020 Aug 24. PubMed PMID: 32786689.

Thompson JD, Ou J, Lee N, Shin K, Cigliola V, Song L, Crawford GE, Kang J, Poss KD. Identification and requirements of enhancers that direct gene expression during zebrafish fin regeneration. Development. 2020 Jul 30;147(14):dev191262. doi: 10.1242/dev.191262. PubMed PMID: 32665240.

Jin N, Lera RF, Yan RE, Guo F, Oxendine K, Horner VL, Hu Y, Wan J, Mattison RJ, Weaver BA, Burkard ME. Chromosomal instability upregulates interferon in acute myeloid leukemia. Genes Chromosomes Cancer. 2020 Nov;59(11):627-638. doi: 10.1002/gcc.22880. Epub 2020 Jul 18. PubMed PMID: 32557940.

Liao R, Zheng Y, Liu X, Zhang Y, Seim G, Tanimura N, Wilson GM, Hematti P, Coon JJ, Fan J, Xu J, Keles S, Bresnick EH. Discovering How Heme Controls Genome Function Through Heme-omics. Cell Rep. 2020 Jun 30;31(13):107832. doi: 10.1016/j.celrep.2020.107832. PubMed PMID: 32610133; PMCID: PMC7382780.

You X, Chang YI, Kong G, Ranheim EA, Zhou Y, Johnson KD, Mehta C, Bresnick EH, Zhang J. Gata2 -77 enhancer regulates adult hematopoietic stem cell survival. Leukemia. 2020 Jun 27. doi: 10.1038/s41375-020-0942-6. Epub ahead of print. PubMed PMID: 32594099.

Fogg KC, Renner CM, Christian H, Walker A, Marty-Santos L, Khan A, Olson WR, Parent C, O’Shea A, Wellik DM, Weisman PS, Kreeger PK. Ovarian Cells Have Increased Proliferation in Response to Heparin-Binding Epidermal Growth Factor as Collagen Density Increases. Tissue Eng Part A. 2020 Jul;26(13-14):747-758. doi: 10.1089/ten.tea.2020.0001. Epub 2020 Jun 25. PubMed PMID: 32598229.

Adriansjach J, Baum ST, Lefkowitz EJ, Van Der Pol WJ, Buford TW, Colman RJ. Age-Related Differences in the Gut Microbiome of Rhesus Macaques. J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1293-1298. doi: 10.1093/gerona/glaa048. PubMed PMID: 32052009.

Ash H, Ziegler TE, Colman RJ. Early learning in the common marmoset (Callithrix jacchus): Behavior in the family group is related to preadolescent cognitive performance. Am J Primatol. 2020 Aug;82(8):e23159. doi: 10.1002/ajp.23159. Epub 2020 Jun 9. PubMed PMID: 32515834.

Garcia PE, Adoumie M, Kim EC, Zhang Y, Scales MK, El-Tawil YS, Shaikh AZ, Wen HJ, Bednar F, Allen BL, Wellik DM, Crawford HC, Pasca di Magliano M. Differential Contribution of Pancreatic Fibroblast Subsets to the Pancreatic Cancer Stroma. Cell Mol Gastroenterol Hepatol. 2020;10(3):581-599. doi: 10.1016/j.jcmgh.2020.05.004. Epub 2020 May 23. PubMed PMID: 32454112.

Jiang P, Chamberlain CS, Vanderby R, Thomson JA, Stewart R. TimeMeter assesses temporal gene expression similarity and identifies differentially progressing genes. Nucleic Acids Res. 2020 May 21;48(9):e51. doi: 10.1093/nar/gkaa142. PubMed PMID: 32123905.

Singh A, Denu RA, Wolfe SK, Sperger JM, Schehr J, Witkowsky T, Esbona K, Chappell RJ, Weaver BA, Burkard ME, Lang JM. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol Oncol. 2020 Aug;14(8):1898-1909. doi: 10.1002/1878-0261.12687. Epub 2020 May 19. PubMed PMID: 32255253; PMCID: PMC7400789.

Aon MA, Bernier M, Mitchell SJ, Di Germanio C, Mattison JA, Ehrlich MR, Colman RJ, Anderson RM, de Cabo R. Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice. Cell Metab. 2020 Jul 7;32(1):100-116.e4. doi: 10.1016/j.cmet.2020.04.018. Epub 2020 May 14. PubMed PMID: 32413334.

Bolus H, Crocker K, Boekhoff-Falk G, Chtarbanova S. Modeling Neurodegenerative Disorders in Drosophila melanogaster. Int J Mol Sci. 2020 Apr 26;21(9):3055. doi: 10.3390/ijms21093055. PubMed PMID: 32357532; PMCID: PMC7246467.

Goodroe AE, Fitz C, Power ML, Colman RJ, Capuano S 3rd, Ziegler TE. Evaluation of vitamin D3 metabolites in Callithrix jacchus (common marmoset). Am J Primatol. 2020 Jun;82(6):e23131. doi: 10.1002/ajp.23131. Epub 2020 Apr 9. PubMed PMID: 32270886

Singh A, Denu RA, Wolfe SK, Sperger JM, Schehr J, Witkowsky T, Esbona K, Chappell RJ, Weaver BA, Burkard ME, Lang JM. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol Oncol. 2020 Apr 7;. doi: 10.1002/1878-0261.12687. [Epub ahead of print] PubMed PMID: 32255253.

Golenberg N, Squirrell JM, Bennin DA, Rindy J, Pistono PE, Eliceiri KW, Shelef MA, Kang J, Huttenlocher A. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020 Apr 6;219(4):e201908164. doi: 10.1083/jcb.201908164. PubMed PMID: 32328635; PMCID: PMC7147109.

Ray S, Chee L, Matson DR, Palermo NY, Bresnick EH, Hewitt KJ. Sterile α-motif domain requirement for cellular signaling and survival. J Biol Chem. 2020 May 15;295(20):7113-7125. doi: 10.1074/jbc.RA119.011895. Epub 2020 Apr 2. PMID: 32241909; PMCID: PMC7242717.

Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F. Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. Cell Metab. 2020 Apr 7;31(4):822-836.e5. doi: 10.1016/j.cmet.2020.03.002. Epub 2020 Mar 26. PubMed PMID: 32220307; PMCID: PMC7346095.

Eshed-Eisenbach Y, Devaux J, Vainshtein A, Golani O, Lee SJ, Feinberg K, Sukhanov N, Greenspan DS, Susuki K, Rasband MN, Peles E. Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by Bone Morphogenetic Protein-1/Tolloid-like Proteinases. Neuron. 2020 Jun 3;106(5):806-815.e6. doi: 10.1016/j.neuron.2020.03.001. Epub 2020 Mar 24. PubMed PMID: 32209430.

Brown KA, Tucholski T, Eken C, Knott S, Zhu Y, Jin S, Ge Y. High-Throughput Proteomics Enabled by a Photocleavable Surfactant. Angew Chem Int Ed Engl. 2020 May 25;59(22):8406-8410. doi: 10.1002/anie.201915374. Epub 2020 Mar 24. PubMed PMID: 32097521

Haws SA, Yu D, Ye C, Wille CK, Nguyen LC, Krautkramer KA, Tomasiewicz JL, Yang SE, Miller BR, Liu WH, Igarashi K, Sridharan R, Tu BP, Cryns VL, Lamming DW, Denu JM. Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence. Mol Cell. 2020 Apr 16;78(2):210-223.e8. doi: 10.1016/j.molcel.2020.03.004. Epub 2020 Mar 23. PubMed PMID: 32208170; PMCID: PMC7191556.

Salamon RJ, Zhang Z, Mahmoud AI. Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging. J Vis Exp. 2020 Mar 17;(157). doi: 10.3791/60482. PubMed PMID: 32250361.

Li M, Shin J, Risgaard R, Parries M, Wang J, Chasman D, Roy S*, Bhattacharyya A*, and Zhao X* (2020) Identification of FMR1 regulated molecular networks in human neurodevelopment, Genome Research 2020 Mar 16 (Online ahead of print). PubMed PMID: 32179589 DOI: 10.1101/gr.251405.119

Song JY, Pineault KM, Dones JM, Raines RT, Wellik DM. Hox genes maintain critical roles in the adult skeleton. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7296-7304. doi: 10.1073/pnas.1920860117. Epub 2020 Mar 13. PubMed PMID: 32170021; PMCID: PMC7132104.

Bhattacharyya A. Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem Cells. Am J Intellect Dev Disabil. 2020 Mar;125(2):90-92. doi: 10.1352/1944-7558-125.2.90. PubMed PMID: 32058817; PMCID: PMC7169307.

Adriansjach J, Baum ST, Lefkowitz EJ, Van Der Pol W, Buford TW, Colman RJ. Age-related differences in the gut microbiome of Rhesus macaques. J Gerontol Biol Sci. 2020 Feb 13. pii:glaa048. doi.org/10.1093/gerona/glaa048. [Epub ahead of print].

Zhang F, Wyche TP, Zhu Y, Braun DR, Yan JX, Chanana S, Ge Y, Guzei IA, Chevrette MG, Currie CR, Thomas MG, Rajski SR, Bugni TS. MS-Derived Isotopic Fine Structure Reveals Forazoline A as a Thioketone-Containing Marine-Derived Natural Product. Org Lett. 2020 Feb 21;22(4):1275-1279. doi: 10.1021/acs.orglett.9b04535. Epub 2020 Feb 4. PubMed PMID: 32017574; PMCID: PMC7494057.

Johnson JM, Hebert AS, Drane QH, Lera RF, Wan J, Weaver BA, Coon JJ, Burkard ME. A Genetic Toggle for Chemical Control of Individual Plk1 Substrates. Cell Chem Biol. 2020 Mar 19;27(3):350-362.e8. doi: 10.1016/j.chembiol.2020.01.007. Epub 2020 Feb 3. PubMed PMID: 32017920.

Rhoads TW, Clark JP, Gustafson GE, Miller KN, Conklin MW, DeMuth TM, Berres ME, Eliceiri KW, Vaughan LK, Duarte CW, Beasley TM, Colman RJ, Anderson RM. Molecular and functional networks linked to sarcopenia prevention by caloric restriction in rhesus monkeys. Cell Systems. 2020 Jan 22. pii: S2405-4712(19)30463-6. doi: 10.1016/j.cells.2019.12.002. [Epub ahead of print].

Dong Y, Xiong M, Chen Y, Tao Y, Li X, Bhattacharyya A, Zhang SC. Plasticity of Synaptic Transmission in Human Stem Cell-Derived Neural Networks. (2020) iScience. 2020 Jan 9;23(2):100829. doi: 10.1016/j.isci.2020.100829. [Epub ahead of print]. PMID:31981924

2019

Brok-Volchanskaya V.S., Bennin D. A., Suknuntha K, Klemm L. C., Huttenlocher A., Slukvin I. Effective and rapid generation of functional neutrophils from induced pluripotent stem cells using ETV2 modified mRNA. Stem Cell Reports. 2019 Dec 10;13(6):1099-1110.

Tran KA, Dillingham CM, Sridharan R. Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity. EMBO J. 2019 Nov 15;38(22):e101681. doi: 10.15252/embj.2019101681. Epub 2019 Oct 4. PubMed PMID: 31583744; PubMed Central PMCID: PMC6856600.

Denomy C, Germain S, Haave B, Vizeacoumar FS, Freywald A, Weaver BA, Vizeacoumar FJ. Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Databases. Cancer Res. 2019 Oct 15;79(20):5181-5190. doi: 10.1158/0008-5472.CAN-19-0585. Epub 2019 Aug 15. PubMed PMID: 31416843.

Pineault KM, Song JY, Kozloff KM, Lucas D, Wellik DM., “Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life” , Nat Commun. 2019 Jul 18;10(1):3168. doi: 10.1038/s41467-019-11100-4.

Berger AJ, Renner CM, Hale I, Yang X, Ponik SM, Weisman PS, Masters KS, Kreeger PK. Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling. Matrix Biol. 2020 Jan;85-86:80-93. doi: 10.1016/j.matbio.2019.07.006. Epub 2019 Jul 16. PubMed PMID: 31323325; PubMed Central PMCID: PMC6962577.

Brandt EB, Bashar SJ, Mahmoud AI. Stimulating ideas for heart regeneration: the future of nerve-directed heart therapy. Bioelectron Med. 2019;5:8. doi: 10.1186/s42234-019-0024-0. eCollection 2019. Review. PubMed PMID: 32232098; PubMed Central PMCID: PMC7098228.

Fogg KC, Olson WR, Miller JN, Khan A, Renner C, Hale I, Weisman PS, Kreeger PK. Alternatively activated macrophage-derived secretome stimulates ovarian cancer spheroid spreading through a JAK2/STAT3 pathway. Cancer Lett. 2019 Aug 28;458:92-101. doi: 10.1016/j.canlet.2019.05.029. Epub 2019 May 24. PubMed PMID: 31129149; PubMed Central PMCID: PMC6659112.

Tran KA, Pietrzak SJ, Zaidan NZ, Siahpirani AF, McCalla SG, Zhou AS, Iyer G, Roy S, Sridharan R. Defining Reprogramming Checkpoints from Single-Cell Analyses of Induced Pluripotency. Cell Rep. 2019 May 7;27(6):1726-1741.e5. doi: 10.1016/j.celrep.2019.04.056. PubMed PMID: 31067459; PubMed Central PMCID: PMC6555151.

Kraynak M, Colman RJ, Flowers MT, Abbott DH, Levine JE. Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys. Int J Obes (Lond). 2019 May;43(5):1034-1045. doi: 10.1038/s41366-018-0156-4. Epub 2018 Jul 18. PubMed PMID: 30022054.

Ren J, Zhou T, Pilli VSS, Phan N, Wang Q, Gupta K, Liu Z, Sheibani N, Liu B. Novel Paracrine Functions of Smooth Muscle Cells in Supporting Endothelial Regeneration Following Arterial Injury. Circ Res. 2019 Apr 12;124(8):1253-1265. doi: 10.1161/CIRCRESAHA.118.314567. PubMed PMID: 30739581; PubMed Central PMCID: PMC6459708.

Rodriguez AM, Kang J. Regeneration enhancers: Starting a journey to unravel regulatory events in tissue regeneration. Semin Cell Dev Biol. 2020 Jan;97:47-54. doi: 10.1016/j.semcdb.2019.04.003. Epub 2019 Apr 8. Review. PubMed PMID: 30953740; PubMed Central PMCID: PMC6783330.

Xu S, Wang G, Peng W, Xu Y, Zhang Y, Ge Y, Jing Y, Gong Z. Corosolic acid isolated from Eriobotrya japonica leaves reduces glucose level in human hepatocellular carcinoma cells, zebrafish and rats. Sci Rep. 2019 Mar 13;9(1):4388. doi: 10.1038/s41598-019-40934-7. PubMed PMID: 30867526.

Pfaltzgraff ER, Apfelbaum A, Kassa AP, Song JY, Jiang W, Suhan TK, Wellik DM, Lawlor ER. Anatomic Origin of Osteochondrogenic Progenitors Impacts Sensitivity to EWS-FLI1-Induced Transformation. Cancers (Basel). 2019 Mar 6;11(3). pii: E313. doi: 10.3390/cancers11030313. PubMed PMID: 30845695.

Zhou T, Wang Q, Phan N, Ren J, Yang H, Feldman CC, Feltenberger JB, Ye Z, Wildman SA, Tang W, Liu B. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell Death Dis. 2019 Mar 6;10(3):226. doi: 10.1038/s41419-019-1468-6. PubMed PMID: 30842407; PubMed Central PMCID: PMC6403222.

Jin Y, Diffee GM, Colman RJ, Anderson RM, Ge Y. Top-down Mass Spectrometry of Sarcomeric Protein Post-translational Modifications from Non-human Primate Skeletal Muscle. J Am Soc Mass Spectrom. 2019 Mar 4. doi: 10.1007/s13361-019-02139-0. [Epub ahead of print] PubMed PMID: 30834509.

Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X. Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Nat Neurosci. 2019 Mar;22(3):386-400. doi: 10.1038/s41593-019-0338-y. Epub 2019 Feb 11. PubMed PMID: 30742117.

Magli A, Baik J, Mills LJ, Kwak IY, Dillon BS, Mondragon Gonzalez R, Stafford DA, Swanson SA, Stewart R, Thomson JA, Garry DJ, Dynlacht BD, Perlingeiro RCR. Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm. PLoS Biol. 2019 Feb 26;17(2):e3000153. doi: 10.1371/journal.pbio.3000153. eCollection 2019 Feb. PubMed PMID: 30807574; PubMed Central PMCID: PMC6390996.

Tucholski T, Knott SJ, Chen B, Pistono P, Lin Z, Ge Y. A Top-Down Proteomics Platform Coupling Serial Size Exclusion Chromatography and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Anal Chem. 2019 Feb 25. doi: 10.1021/acs.analchem.8b04082. [Epub ahead of print] PubMed PMID: 30758949.

Hall PE, Lewis R, Syed N, Shaffer R, Evanson J, Ellis S, Williams M, Feng X, Johnston A, Thomson JA, Harris FP, Jena R, Matys T, Jefferies S, Smith K, Wu BW, Bomalaski JS, Crook T, O’Neill K, Paraskevopoulos D, Khadeir RS, Sheaff M, Pacey S, Plowman PN, Szlosarek PW. A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma. Clin Cancer Res. 2019 Feb 22. doi: 10.1158/1078-0432.CCR-18-3729. [Epub ahead of print] PubMed PMID: 30796035.

Incitti T, Magli A, Darabi R, Yuan C, Lin K, Arpke RW, Azzag K, Yamamoto A, Stewart R, Thomson JA, Kyba M, Perlingeiro RCR. Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment. Proc Natl Acad Sci U S A. 2019 Feb 13. pii: 201808303. doi: 10.1073/pnas.1808303116. [Epub ahead of print] PubMed PMID: 30760602.

Soukup AA, Zheng Y, Mehta C, Wu J, Liu P, Cao M, Hofmann I, Zhou Y, Zhang J, Johnson KD, Choi K, Keles S, Bresnick EH. Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer. J Clin Invest. 2019 Mar 1;129(3):1180-1192. doi: 10.1172/JCI122694. Epub 2019 Feb 11. PubMed PMID: 30620726; PubMed Central PMCID: PMC6391105.

Dansereau G, Wey TW, Legault V, Brunet MA, Kemnitz JW, Ferrucci L, Cohen AA. Conservation of physiological dysregulation signatures of aging across primates. Aging Cell. 2019 Apr;18(2):e12925. doi: 10.1111/acel.12925. Epub 2019 Feb 11. PubMed PMID: 30746836.

Liang Y, Jin Y, Wu Z, Tucholski T, Brown KA, Zhang L, Zhang Y, Ge Y. Bridged Hybrid Monolithic Column Coupled to High-Resolution Mass Spectrometry for Top-Down Proteomics. Anal Chem. 2019 Feb 5;91(3):1743-1747. doi: 10.1021/acs.analchem.8b05817. Epub 2019 Jan 28. PubMed PMID: 30668094.

Churpek JE, Bresnick EH. Transcription factor mutations as a cause of familial myeloid neoplasms. J Clin Invest. 2019 Feb 1;129(2):476-488. doi: 10.1172/JCI120854. Epub 2019 Feb 1. Review. PubMed PMID: 30707109; PubMed Central PMCID: PMC6355228.

Ozay EI, Vijayaraghavan J, Gonzalez-Perez G, Shanthalingam S, Sherman HL, Garrigan DT Jr, Chandiran K, Torres JA, Osborne BA, Tew GN, Slukvin II, Macdonald RA, Kelly K, Minter LM. Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease. Stem Cell Res. 2019 Mar;35:101401. doi: 10.1016/j.scr.2019.101401. Epub 2019 Feb 1. PubMed PMID: 30738321.

Saltzman W, Abbott DH, Binkley N, Colman RJ. Maintenance of bone mass despite estrogen depletion in female common marmoset monkeys (Callithrix jacchus). Am J Primatol. 2019 Feb;81(2):e22905. doi: 10.1002/ajp.22905. Epub 2018 Aug 14. PubMed PMID: 30106167.

Kong F, Yamaoka Y, Ohama T, Lee Y, Li-Beisson Y. Molecular Genetic Tools and Emerging Synthetic Biology Strategies to Increase Cellular Oil Content in Chlamydomonas reinhardtii. Plant Cell Physiol. 2019 Jan 31. doi: 10.1093/pcp/pcz022. [Epub ahead of print] PubMed PMID: 30715500.

Cho E, Kang H, Kang DK, Lee Y. Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. J Biol Chem. 2019 Mar 29;294(13):4981-4996. doi: 10.1074/jbc.RA118.005634. Epub 2019 Jan 30. PubMed PMID: 30700554; PubMed Central PMCID: PMC6442036.

Tang TWH, Chen HC, Chen CY, Yen CYT, Lin CJ, Prajnamitra RP, Chen LL, Ruan SC, Lin JH, Lin PJ, Lu HH, Kuo CW, Chang CM, Hall AD, Vivas EI, Shui JW, Chen P, Hacker TA, Rey FE, Kamp TJ, Hsieh PCH. Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair. Circulation. 2019 Jan 29;139(5):647-659. doi: 10.1161/CIRCULATIONAHA.118.035235. PubMed PMID: 30586712.

Mi HY, Jing X, Li ZT, Lin YJ, Thomson JA, Turng LS. Fabrication and modification of wavy multicomponent vascular grafts with biomimetic mechanical properties, antithrombogenicity, and enhanced endothelial cell affinity. J Biomed Mater Res B Appl Biomater. 2019 Jan 28. doi: 10.1002/jbm.b.34333. [Epub ahead of print] PubMed PMID: 30689292.

Joseph DB, Chandrashekar AS, Abler LL, Chu LF, Thomson JA, Vezina CM. Epithelial DNA methyltransferase-1 regulates cell survival, growth and maturation in developing prostatic buds. Dev Biol. 2019 Jan 16. pii: S0012-1606(18)30719-X. doi: 10.1016/j.ydbio.2019.01.011. [Epub ahead of print] PubMed PMID: 30659795.

Cox BL, Erickson-Bhatt S, Szulczewski JM, Squirrell JM, Ludwig KD, Macdonald EB, Swader R, Ponik SM, Eliceiri KW, Fain SB. A novel bioreactor for combined magnetic resonance spectroscopy and optical imaging of metabolism in 3D cell cultures. Magn Reson Med. 2019 May;81(5):3379-3391. doi: 10.1002/mrm.27644. Epub 2019 Jan 16. PubMed PMID: 30652350.

Gregorich ZR, Patel JR, Cai W, Lin Z, Heurer R, Fitzsimons DP, Moss RL, Ge Y. Deletion of Enigma Homologue from the Z-disc slows tension development kinetics in mouse myocardium. J Gen Physiol. 2019 Jan 14. pii: jgp.201812214. doi: 10.1085/jgp.201812214. [Epub ahead of print] PubMed PMID: 30642915.

Song JY, Pineault KM, Wellik DM. Development, repair, and regeneration of the limb musculoskeletal system. Curr Top Dev Biol. 2019;132:451-486. doi: 10.1016/bs.ctdb.2018.12.011. Epub 2019 Jan 11. PubMed PMID: 30797517.

Ge Y, Schuster MB, Pundhir S, Rapin N, Bagger FO, Sidiropoulos N, Hashem N, Porse BT. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia. Nat Commun. 2019 Jan 11;10(1):172. doi: 10.1038/s41467-018-08076-y. PubMed PMID: 30635567; PubMed Central PMCID: PMC6329799.

Lee JJ, Cheng SJ, Huang CY, Chen CY, Feng L, Hwang DY, Kamp TJ, Chen HC, Hsieh PCH. Primary cardiac manifestation of autosomal dominant polycystic kidney disease revealed by patient induced pluripotent stem cell-derived cardiomyocytes.EBioMedicine. 2019 Feb;40:675-684. doi: 10.1016/j.ebiom.2019.01.011. Epub 2019 Jan 11. PubMed PMID: 30639418.

Giles J, Patel JR, Miller A, Iverson E, Fitzsimons D, Moss RL. Recovery of left ventricular function following in vivo reexpression of cardiac myosin binding protein C. J Gen Physiol. 2019 Jan 7;151(1):77-89. doi: 10.1085/jgp.201812238. Epub 2018 Dec 20. PubMed PMID: 30573635; PubMed Central PMCID: PMC6314388.

Berry JL, Zhu W, Tang YL, Krishnamurthy P, Ge Y, Cooke JP, Chen Y, Garry DJ, Yang HT, Rajasekaran NS, Koch WJ, Li S, Domae K, Qin G, Cheng K, Kamp TJ, Ye L, Hu S, Ogle BM, Rogers JM, Abel ED, Davis ME, Prabhu SD, Liao R, Pu WT, Wang Y, Ping P, Bursac N, Vunjak-Novakovic G, Wu JC, Bolli R, Menasché P, Zhang J. Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure. Circ Res. 2019 Jan 4;124(1):161-169. doi: 10.1161/CIRCRESAHA.118.314216. PubMed PMID: 30605412; PubMed Central PMCID: PMC6350935.

Sun J, Carlson-Stevermer J, Das U, Shen M, Delenclos M, Snead AM, Koo SY, Wang L, Qiao D, Loi J, Petersen AJ, Stockton M, Bhattacharyya A, Jones MV, Zhao X, McLean PJ, Sproul AA, Saha K, Roy S. CRISPR/Cas9 editing of APP C-terminus attenuates β-cleavage and promotes α-cleavage. Nat Commun. 2019 Jan 3;10(1):53. doi: 10.1038/s41467-018-07971-8. PubMed PMID: 30604771; PubMed Central PMCID: PMC6318289.

Yin Y, Petersen AJ, Soref C, Richards WD, Ludwig T, Taapken S, Berndt E, Zhang SC, Bhattacharyya A.*(2019) Generation of seven induced pluripotent stem cell lines from neonates of different ethnic backgrounds. Stem Cell Res. 2019 Jan;34:101365. doi: 10.1016/j.scr.2018.101365. Epub 2018 Dec 20. PubMed PMID: 30605841.