Position title: Professor - Biomedical Engineering
Phone: Phone: (608) 890-2915 | Fax: (608) 265-9239
RESEARCH INTERESTS - Systems biology, cell-cell interactions, tumor microenvironment, ovarian cancer, collective migration
UW Carbone Cancer Center
Postdoctoral Fellowship, Biological Engineering, MIT, 2005-2008
Ph.D. Chemical Engineering, Northwestern University, 2005
B.S. Chemistry, Valparaiso University, 2000
The Kreeger lab utilizes systems biology and tissue engineering to analyze cellular behavior in a variety of biological contexts. We utilize an iterative approach, where we develop model culture systems that allow us to study a disease in a controlled environment, use high-throughput experimental methods to gather information about the cellular signaling network and cellular responses, and employ computational models to interpret the data. Ultimately, our models will be utilized to identify new drug targets, match patients to the most effective drugs, and identify methods to direct cellular behavior.
- CS Kim, IP Mitchell, A Desotell, PK Kreeger, KS Masters. “Immobilized EGF stimulates persistent, directed keratinocyte migration via activation of PLCg1.” FASEBJ. 30, p 2580-2590. 2016.
- MJ Carroll, K Fogg, H Patel, HB Krause, A-S Mancha, M Patankar, PS Weisman, L Barroilhet, and PK Kreeger. Alternatively activated macrophages upregulate mesothelial expression of P-selectin to enhance adhesion of ovarian cancer cells. Cancer Research. 78(13), p. 3560-3573. 2018.
- KM Fogg, WR Olson, JN Miller, A Khan, C Renner, I Hale, PS Weisman, PK Kreeger. Alternatively activated macrophage-derived secretome stimulates ovarian cancer spheroid spreading through a JAK2/STAT3 pathway. Cancer Letters. 458. p. 92-101. 2019.
- AJ Berger, CM Renner, I Hale, X Yang, SM Ponik, PS Weisman, KS Masters, PK Kreeger. “Scaffold stiffness influences breast cancer cell invasion via EGFR-linked Mena upregulation and matrix remodeling.” Matrix Biology. pii: S0945-053X(19)30104-0. 2019.
For a complete list of Dr. Kreeger’s publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/pamela.kreeger.1/bibliograpahy/43013971/public/?sort=date&direction=descending