Cell and Regenerative Biology
School of Medicine and Public Health

Ricki Colman

Position title: Associate Professor

Email: rcolman@primate.wisc.edu

Phone: Phone: (608) 263-3544

Address:
RESEARCH INTERESTS - Energy regulation and the impact of caloric restriction on aging in nonhuman primates

Ricki Colman

 

Address: 213 Wisconsin Primate Center – 1223 Capitol Ct. – Madison, WI 53715

PubMed

Education

B.A., 1991, Washington University, St. Louis, MO, Biology and Anthropology
M.A., 1993, Washington University, St. Louis, MO, Biological Anthropology
M.S., 1998, University of Wisconsin – Madison, WI, Biological Anthropology
Ph.D., 1998, University of Wisconsin – Madison, WI, Biological Anthropology

Research

My laboratory at the Wisconsin National Primate Research Center utilizes nonhuman primate models to explore the impact of nutrition and metabolism on health across the aging continuum. The bulk of my research has focused on later life time points and the ability of caloric restriction to modulate the aging process. Caloric restriction, undernutrition without malnutrition, offers a powerful way to explore mechanisms of aging because it is the only environmental intervention that repeatedly and strongly increases maximum life span and delays aging in a diverse array of experimental organisms. My lab runs one of only two ongoing, long-term studies of the effects of moderate caloric restriction on aging in rhesus monkeys. I have more recently begun to explore the impact of nutrition on early life growth and development using a small New World primate model – the common marmoset.

Representative Publications

  • Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, Weindruch R. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science. 325:201-204, 2009. PMCID:PMC2812811.
  • Colman RJ, Beasley TM, Allison DB, Weindruch R. Skeletal effects of long-term caloric restriction in rhesus monkeys. AGE. 34(5):1133-1143, 2012. PMCID:PMC3448987.
  • Ziegler TE, Sosa ME, Peterson LJ, Colman RJ. Using snacks high in fat and protein to improve glucoregulatory function in adolescent male marmosets (Callithrix jacchus). J Am Assoc Lab Anim Sci. 52(6):756-762, 2013. PMCID:PMC3838610.
  • Colman RJ, Beasley TM, Kemnitz JW, Johnson SC, Weindruch R, Anderson RM. Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nat Commun. 5:3557, 2014. doi:10.1038/ncomms4557. PMCID:PMC3988801.
  • Mattison JA*, Colman RJ*, Beasley TM, Allison DB, Kemnitz JW, Roth GS, Ingram DK, Weindruch R, deCabo R, Anderson RM. Caloric restriction improves health and survival of rhesus monkeys. Nature Commun. 8:14063, 2017. doi:10.1038/ncomms14063. PMCID:PMC5247583.
  • Yamada Y, Kemnitz JW, Weindruch R, Anderson RM, Schoeller DA, Colman RJ. Caloric restriction and healthy lifespan: frail phenotype of non-human primates in the Wisconsin National Primate Research Center caloric restriction study. J Gerontol Biol Sci. 73(3):273-278, 2018. doi:10.1093/gerona/glx059. PMCID:PMC5861888.
  • Schneider A, Dhahbi JM, Atamna H, Clark JP, Colman RJ, Anderson RM. Caloric restriction impacts plasma microRNAs in rhesus monkeys. Aging Cell. 16(5):1200-1203, 2017. doi:10.1111/acel.12636. PMCID:PMC5595684.
  • Colman RJ. Non-human primates as a model for aging. Biochim Biophys Acta. 1864(9 Pt A):2733-2741, 2018. doi:10.1016/j.bbadis.2017.07.008. PMCID:PMC5772001.
  • Maegawa S, Lu Y, Tahara T, Lee JT, Madzo J, Liang S, Jelinek JJ, Colman RJ, Issa J-PJ. Caloric restriction delays age-related methylation drift. Nature Commun. 8(1):539, 2017. doi:10.1038/s41467-017-00607-3. PMCID:PMC5599616.
  • Ziegler TE, Sosa ME, Colman RJ. Fathering style influences health outcome in common marmoset (Callithrix jacchus) offspring. PLoS One. 12(9):e0185695, 2017. doi:10.1371/journal.pone.0185695. PMCID:PMC5619809.
  • Rhoads TW, Burhans MS, Chen VB, Hutchins PD, Rush MJP, Clark JP, Stark JL, McIlwain SJ, Eghbalnia HR, Pavelec DM, Ong IM, Denu JM, Markley JL, Coon JJ, Colman RJ, Anderson RM. Caloric restriction engages hepatic RNA processing mechanisms in rhesus monkeys. Cell Metab. 27(3):677-688, 2018. Doi:10.1016/j.cmet.2018.01.014. PMCID:PMC5844481.
  • Kraynak M*, Colman RJ*, Flowers MT, Abbott DH, Levine JE. Ovarian estradiol supports sexual behavior but not energy homeostasis in female marmoset monkeys. Int J Obesity. 43(5):1034-1045, 2019. doi:10.1038/s41366-018-0156-4. PMCID in progress.
  • Saltzman W, Abbott DH, Binkley N, Colman RJ. Maintenance of bone mass despite estrogen depletion in female common marmoset monkeys (Callithrix jacchus). Am J Primatol. 81(2):e22905, 2019. doi:10.1002/ajp.22905.
  • Rhoads TW, Clark JP, Gustafson GE, Miller KN, Conklin MW, DeMuth TM, Berres ME, Eliceiri KW, Vaughan LK, Duarte CW, Beasley TM, Colman RJ, Anderson RM. Molecular and functional networks linked to sarcopenia prevention by caloric restriction in rhesus monkeys. Cell Systems. 2020 Jan 22. pii: S2405-4712(19)30463-6. doi: 10.1016/j.cells.2019.12.002. [Epub ahead of print].
  • Adriansjach J, Baum ST, Lefkowitz EJ, Van Der Pol W, Buford TW, Colman RJ. Age-related differences in the gut microbiome of Rhesus macaques. J Gerontol Biol Sci. 2020 Feb 13. pii:glaa048. doi.org/10.1093/gerona/glaa048. [Epub ahead of print].
  • Tao T, Sato R, Matsuda Y, Takata J, Kim F, Daikubara Y, Fujita K, Hanamoto K, Kinoshita F, Colman R, Koshiba M. Elderly body movement alteration at 2nd experience of digital art installation with cognitive and motivation scores. J-Multidisciplinary Sci J. 3(2):138-150, 2020. doi:10.3390/j3020012.
  • Aon MA, Bernier M, Mitchell SJ, Di Germanio C, Mattison JA, Ehrlich M, Colman RJ, Anderson RM, de Cabo R. Untangling determinants of enhanced health and lifespan through a multi-omics approach in mice. Cell Metab.32:1-17, 2020. doi:10.1016/j.cmet.2020.04.018. PMCID:PMC8214079. 
  • Ash H, Ziegler T, Colman RJ. Early learning in the common marmoset (Callithrix jacchus): effect of sex and family interactions on cognitive development. Am J Primatol. 2020 Jun 9:e23159. doi:10.1002/ajp.23159. PMCID:PMC7440670
  • Havton LA, Biscola NP, Christe KL, Capuano S, Colman RJ. Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques. PLoS One. 2020 Sep 21;15(9):e0236430. doi:10.1371/journal.pone.0236430. PMCID:PMC7505584. 
  • Karino G, Senoo A, Kunikata T, Kamei Y, Yamanouchi H, Nakamura S, Shukuya M, Colman RJ, Koshiba M. Inexpensive home infrared living/environment sensor with regional thermal information for infant physical and psychological development. Int J Env Res Pub Health 17(18):6844, 2020. doi:10.3990/ijerph17186844. PMCID:PMC7559736.
  • Colman RJ, Capuano S, Bakker J, Keeley J, Nakamura K, Ross C. Marmosets: welfare, ethical use, and IACUC/regulatory considerations. ILARJ. 2021 Feb 23;ilab003. doi:10.1093/ilar/ilab003. PMCID:PMC9214643. 
  • Ross CN, Colman RJ, Power M, Tardif S. Marmoset metabolism, nutrition and obesity. ILARJ. 2021 May 10;ilab014. doi:10.1093/ilar/ilab014. PMCID:PMC8918150. 
  • Goodroe A, Wachtman L, Allen-Worthington K, Bakker J, Burns M, Diaz LL, Dick E, Dickerson M, Eliades SJ, Gonzalez O, Graf D, Haroush K, Inoue T, Izzi J, Laudano A, Layne-Colon D, Leblanc M, Ludwig B, Mejia A, Miller C, Sarfaty A, Sosa M, Vallender E, Brown C, Forney L, Schultz-Darken N, Colman R, Power M, Capuano S, Ross C, Tardif S. Current practices in nutrition management and disease incidence of common marmosets (Callithrix jacchus). J Med Primatol. 50:164-175, 2021. doi.org/1111/jmp.12525. PMCID:PMC8422998. 
  • Bliss-Moreau E, Amara RR, Buffalo EA, Colman RJ, Embers ME, Morrison JH, Quillen EE, Sacha JB, Roberts CT. Improving rigor and reproducibility in nonhuman primate research. American Journal of Primatology. 83(12):E23331, 2021. doi:10.1002/ajp.23331. PMCID:PMC8629848. 
  • Souder DC, Dreischmeier IA, Smith AB, Wright S, Martin SA, Sagar MAK, Eliceiri KW, Salamat SM, Bendlin BB, Colman RJ, Beasley TM, Puglielli L, Anderson RM. Rhesus monkeys as a translational model for late-onset Alzheimer’s disease. Aging Cell. 2021;00:e13374. doi:10.1111/acel.13374. PMCID:PMC8208787. 
  • Palliyaguru DL, Shiroma EJ, Nam JK, Duregon E, Teixeira CVL, Price NL, Bernier M, Camandola S, Vaughan KL, Colman RJ, Deighan A, Korstanje R, Peters LL, Dickinson SL, Ejima K, Simonsick EM, Launer LJ, Chia CW, Egan J, Allison DB, Churchill GA, Anderson RM, Ferruci L, Mattison JA, deCabo R. Fasting blood glucose as a predictor of mortality: lost in translation. Cell Metab. 33:1-12, 2021. PMCID:PMC9115768. 
  • Goy RW, Shrestha HK, Ziegler TE, Dukes NJ, Colman RJ, Kapoor A. Development and validation of an LC-MS/MS based quantitative assay for marmoset insulin. J Chromatography B Analyt Technol Biomed Life Sci. Apr 15, 2022;1195:123150. PMCID:PMC8958664. 
  • Balasubramanian P, Schaar AE, Gustafson GE, Smith AB, Howell PR, Greenman A, Baum S, Colman RJ, Lamming DW, Diffee G, Anderson RM. Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice. eLife. Mar 17, 2022;11:271282. PMCID:PMC8963882. 
  • Dukes NJ, Ash H, Oliveira GdF, Sosa ME, Goy RW, Colman RJ, Ziegler TE. Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset father, Callithrix jacchus. Horm Beh. 2022 Mar 30;142:105162. doi:10.1016/j.yhbeh.2022.105162. PMCID:PMC9177807. 
  • Kraynak M, Willging MM, Kuehlmann AL, Kapoor AA, Flowers MT, Colman RJ, Levine JE, Abbott DH. Aromatase inhibition eliminates sexual receptivity without enhancing weight gain in ovariectomized marmoset monkeys. J Endo Soc. 2022 Apr 22;6(6):bvac063. doi: 10.1210/jendso/bvac063. PMCID: PMC9113444. 
  • Ash H, Chang A, Ortiz RJ, Kulkarni P, Rauch B, Colman R, Ferris CF, Ziegler TE. Structural and functional variations in the prefrontal cortex are associated with learning in pre-adolescent common marmosets (Callithrix jacchus). Behav Brain Res. 2022 Jul 26;430:113920. doi: 10.1016/j.bbr.2022.113920. Epub 2022 May 18. PMCID:PMC9362994. 
  • Smith AB, Schill JP, Gordillo R, Gustafson GE, Rhoads TW, Burhans MS, Broman AT, Colman RJ, Scherer PE, Anderson RM. Ceramides are early responders in metabolic syndrome development in rhesus monkeys. Sci Rep. 2022 Jun 15;12(1):9960. doi: 10.1038/s41598-022-14083-3. PMID: 35705631; PMCID:PMC9200850. Goodroe AE, Fitz C, Power ML, Colman RJ, Capuano S, Ziegler TE. Evaluation of Vitamin D3 metabolites in Callithrix jacchus (common marmoset). Am J Primatol. 2020 82:e23131. doi:10.1002/ajp.23131. PMCID:PMC7384697. 
  • Hua Z, Tao T, Akita R, Akita T, Hayakawa Y, Hariyama M, Sakurai H, Colman R, Koshiba M. Four temporary waterslide designs adapted to different slope conditions to encourage child socialization in playgrounds. J Vis Exp, 190:e64235, 2022. doi:10.3791/64235. 
  • Ausderau KK, Colman RJ, Kabakov S, Schultz-Darken N, Emborg ME. Evaluating depression- and anxiety-like behaviors in non-human primates. Front Behav Neurosci. 2023 Jan 19;16:1006065. doi: 10.3389/fnbeh.2022.1006065. PMID: 36744101; PMCID: PMC9892652.
  • Biscola NP, Bartmeyer PM, Christe KL, Colman RJ, Havton LA. Detrusor underactivity is associated with metabolic syndrome in aged primates. Sci Rep. 2023 Apr 25;13(1):6716. doi: 10.1038/s41598-023-33112-3. PMID: 37185781; PMCID: PMC10130177.
  • Pergande MR, Osterbauer KJ, Buck KM, Roberts DS, Wood NN, Balasubramanian P, Mann MW, Rossler K, Diffee GM, Colman RJ, Anderson RM, Ge Y. Mass spectrometry-based multi-omics identifies metabolic signatures of sarcopenia in rhesus monkey skeletal muscle. bioRxiv [Preprint]. 2023 Jul 31:2023.07.31.551315. doi: 10.1101/2023.07.31.551315. PMID: 37577600; PMCID: PMC10418093.
  • Colman R, Pierre P, Adriansjach J, Crosno K, Noguchi KK, Ikonomidou C. Behavioral and Cognitive Outcomes of Rhesus Macaques Following Neonatal Exposure to Antiseizure Medications. Ann Neurol. 2023 Sep 14. doi: 10.1002/ana.26794. Epub ahead of print. PMID: 37706347.
  • Yoda M, Kamei Y, Sakurai H, Kakei H, Tao T, Yamanouchi H, Kunikata T, Hariyama M, Colman R, Koshiba M. A Common Marmoset Model of Mother-Infant Intervention for Breastfeeding Disorders in the Presence of Paternal Inhibition and Maternal Neglect. J Vis Exp. 2023 Sep 22;(199). doi: 10.3791/64232. PMID: 37811967.
  • Ash H, Goy RW, Spaulding A, Colman RJ, Corbett CJ, Ziegler TE. Cognitive development from infancy to young adulthood in common marmosets (Callithrix jacchus): Effect of age, sex, and hormones on learning and affective state. Dev Psychobiol. 2023 Nov;65(7):e22430. doi: 10.1002/dev.22430. PMID: 37860906.