Professor - Surgery
Phone: (608) 263-5931
RESEARCH INTERESTS - Biology of blood vessels, inflammation, intracellular signaling, cell death, cell-cell communications, extracellular matrix protein biology.
MS, Biology, Beijing University, Beijing, China, 1986
PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999
The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, cell-cell signaling via extracellular vesicles, vascular inflammation, thrombosis, progenitor cell recruitment, matrix biology, as well as therapeutic development. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.
- Wang Q, Liu Z, Ren J, Morgan S, Assa C and Liu B. Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysm via smooth muscle cell necrosis and inflammation. Circ Res 2015 116:600-611 (PMC4329096)
- Liu Z, Morgan S, Ren J, Wang Q, Annis DS, Mosher DF, Zheng J, Sorenson CM, Sheibani N, and Liu B. Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell mobility in mouse models of abdominal aortic aneurysm. Circ Res 2015 117:129-41 (PMC4490953)
- Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assar C, Kent KC, and Liu B. Inhibition of receptor-interacting protein kinase 1 with necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Scientific Reports 2017 7:42159 (PMC5301478)
- Zhou T, Wang Q, Phan N, Ren J, Yang H, Feldman CC, Feltenberger JB, Ye Z, Wildman SA, Tang W, and Liu B. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell Death and Disease 2019 10:226 (PMC6403222)
- Ren J, Zhou T, Pilli VS, Phan NM, Wang Q, Gupta K, Liu Z, Sheibani N, Liu B. Novel paracrine functions of smooth muscle cells in supporting endothelial regeneration following arterial injury. Circ Res 2019 124:1253-1265 (PMC6459708)