Professor - Surgery
Phone: (608) 263-5931
RESEARCH INTERESTS - Biology of blood vessels: cellular and molecular pathologies of restenosis and abdominal aortic aneurysm.
MS, Biology, Beijing University, Beijing, China, 1986
PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999
The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, vascular inflammation, progenitor cell recruitment, as well as matrix biology. Additional research interests are gene therapy and nanotechnology. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.
- Local CXCR4 Upregulation in the Injured Arterial Wall Contributes to Intimal Hyperplasia.
Shi X, Guo LW, Seedial S, Takayama T, Wang B, Zhang M, Franco SR, Si Y, Chaudhary MA, Liu B, Kent KC
Stem Cells 2016 Nov; 34(11):2744-2757.
[PubMed ID: 27340942, PMC ID: 5113668]
- Periadventitial drug delivery for the prevention of intimal hyperplasia following open surgery.
Chaudhary MA, Guo LW, Shi X, Chen G, Gong S, Liu B, Kent KC
J Control Release 2016 Jul 10; 233():174-80.
[PubMed ID: 27179635, PMC ID: 4912910]
- Andrographolide Ameliorates Abdominal Aortic Aneurysm Progression by Inhibiting Inflammatory Cell Infiltration through Downregulation of Cytokine and Integrin Expression.
Ren J, Liu Z, Wang Q, Giles J, Greenberg J, Sheibani N, Kent KC, Liu B
J. Pharmacol. Exp. Ther. 2016 Jan; 356(1):137-47.
[PubMed ID: 26483397, PMC ID: 4702070]
- Polymer Multilayers that Promote the Rapid Release and Contact Transfer of DNA.
Yu Y, Si Y, Bechler SL, Liu B, Lynn DM
Biomacromolecules 2015 Sep 14; 16(9):2998-3007.
[PubMed ID: 26285737, PMC ID: 4753844]
- Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell motility in mouse models of abdominal aortic aneurysm.
Liu Z, Morgan S, Ren J, Wang Q, Annis DS, Mosher DF, Zhang J, Sorenson CM, Sheibani N, Liu B
Circ. Res. 2015 Jul 03; 117(2):129-41.
[PubMed ID: 25940549, PMC ID: 4490953]
- Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysms via smooth muscle cell necrosis and inflammation.
Wang Q, Liu Z, Ren J, Morgan S, Assa C, Liu B
Circ. Res. 2015 Feb 13; 116(4):600-11.
[PubMed ID: 25563840, PMC ID: 4329096]
- TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A.
Shi X, Guo LW, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B, Kent KC
Cell Death Dis 2014 Jul 10; 5():e1317.
[PubMed ID: 25010983, PMC ID: 4123076]
- Murine abdominal aortic aneurysm model by orthotopic allograft transplantation of elastase-treated abdominal aorta.
Liu Z, Wang Q, Ren J, Assa CR, Morgan S, Giles J, Han Q, Liu B
J. Vasc. Surg. 2015 Dec; 62(6):1607-14.e2.
[PubMed ID: 24974783, PMC ID: 4277509]
- Monocyte chemoattractant protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm.
Wang Q, Ren J, Morgan S, Liu Z, Dou C, Liu B
PLoS ONE 2014; 9(3):e92053.
[PubMed ID: 24632850, PMC ID: 3954911]
- Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis.
Shi X, Chen G, Guo LW, Si Y, Zhu M, Pilla S, Liu B, Gong S, Kent KC
PLoS ONE 2014; 9(2):e89227.
[PubMed ID: 24586612, PMC ID: 3931710]