Bo Liu

Liu Lab Website

Address: 4431 WIMR – 1111 Highland Ave. – Madison, WI 53705

Education

MS, Biology, Beijing University, Beijing, China, 1986
PhD, Biochemistry, SUNY Downstate, New York, NY, 1993
Postdoctoral fellow, Signal transduction; protein degradation, Columbia University, New York, NY, 1994-1996
Postdoctoral fellow, Transcription regulation; signal transduction, Memorial Sloan-Kettering Cancer Center, New York, NY, 1996-1999

Research

The primary focus of Dr. Liu’s research is the biology of blood vessels. Specifically, Dr. Liu and her trainees study the cellular and molecular pathologies of restenosis and abdominal aortic aneurysm, two common vascular disorders that are in critical need of effective pharmacological treatments. Their experimental approach combines in vitro molecular and biochemical methodologies with transgenic, gene knockout, adenoviral and surgical technologies. Current research topics include cell apoptosis, programmed necrosis, cell-cell signaling via extracellular vesicles, vascular inflammation, thrombosis, progenitor cell recruitment, matrix biology, as well as therapeutic development. To effectively study human disease, Dr. Liu has established productive collaborations with basic scientists and clinicians from a wide range of scientific and medical disciplines. Dr. Liu is also a devoted mentor, whose lab environment fosters creative thinking, multidisciplinary approaches, independence, and collaboration.

Recent Publications

• Wang Q, Liu Z, Ren J, Morgan S, Assa C and Liu B. Receptor-interacting protein kinase 3 contributes to abdominal aortic aneurysm via smooth muscle cell necrosis and inflammation. Circ Res 2015 116:600-611 (PMC4329096)
• Liu Z, Morgan S, Ren J, Wang Q, Annis DS, Mosher DF, Zheng J, Sorenson CM, Sheibani N, and Liu B. Thrombospondin-1 (TSP1) contributes to the development of vascular inflammation by regulating monocytic cell mobility in mouse models of abdominal aortic aneurysm. Circ Res  2015 117:129-41 (PMC4490953)
• Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assar C, Kent KC, and Liu B. Inhibition of receptor-interacting protein kinase 1 with necrostatin-1s ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Scientific Reports 2017 7:42159 (PMC5301478)
• Zhou T, Wang Q, Phan N, Ren J, Yang H, Feldman CC, Feltenberger JB, Ye Z, Wildman SA, Tang W, and Liu B. Identification of a novel class of RIP1/RIP3 dual inhibitors that impede cell death and inflammation in mouse abdominal aortic aneurysm models. Cell Death and Disease 2019 10:226 (PMC6403222)
• Ren J, Zhou T, Pilli VS, Phan NM, Wang Q, Gupta K, Liu Z, Sheibani N, Liu B. Novel paracrine functions of smooth muscle cells in supporting endothelial regeneration following arterial injury. Circ Res 2019 124:1253-1265 (PMC6459708)
• Franco S, Stranz A, Ljumani F, Urabe G, Chaudhary M, Stewart D, Pilli VS, Kelly M, Yamanouchi D, Kent KC, and Liu B, Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury. Heliyon 2020 6(6):e04028 (PMC7303564)
• Khoury MK, Zhou T, Yang H, Prince SR, Gupta K, Stranz AR, Wang Q, and Liu B. GSK2593074A Blocks Progression of Existing Abdominal Aortic Dilation. JVS- Vascular Science. 2020 1:123-135 (PMC7872141)
• Yang H, Zhou T, Sorenson CM, Sheibani N, and Liu B. Myeloid-derived TSP1 (thrombosospondin-1) contributes to abdominal aortic aneurysm through suppressing tissue inhibitor of metalloproteinases-1. Arterioscler Thromb Vasc Biol 2020 40:e350-e366 (PMC7686278)
• Yang H, Zhou T, DeRoo, E, and Liu B. Single-cell RNA sequencing reveals heterogeneity of vascular cells in early stage murine abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol 2021 41:1158-1166 (PMC7904588)
• Gupta K and Liu B. PLK1-mediated S369 phosphorylation of RIPK3 during G2 and M phases enables its Ripoptosome incorporation and activity. iScience 2021 24:102320 (PMC8040267)