Position title: George R. and Elaine Love Professor- Department of Medicine, Division of Allergy, Pulmonary and Critical Care Medicine; Chair - Department of Medicine
RESEARCH INTERESTS: Acute Lung Injury
Address: UW MED FNDTN CENTENNIAL BLDG – 1685 HIGHLAND AVE – MADISON, WI 53705-2281
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S.B., Massachusetts Institute of Technology
M.D., University of Pennsylvania School of Medicine
Dr. Schnapp’s research broadly focuses on the processes that govern acute lung injury and its resolution. More specifically, she investigates how scar tissue forms during lung injury and diseases that damage lung function, such as idiopathic pulmonary fibrosis.
Using unique mouse models to identify cells and pathways that may be potential targets for lung injury, Dr. Schnapp’s research incorporates state-of-the-art computational and pathway-focused network analysis to lung proteomics and transcriptomics data in order to identify novel pathways involved in lung diseases such as ARDS, sarcoidosis, and ventilator associated pneumonia.
More recently, her work has focused on the origin of lung myofibroblasts, and performed key fate mapping experiments demonstrating the importance of pericytes as myofibroblast progenitors in the lung. Her ongoing work is focused on understanding the roles of pericytes in the immune response and fibrotic response in the lung.
The lab is also investigating the link between HIV infection and development of emphysema, and has demonstrated that pericytes are a likely reservoir for the virus in the lung.