Beth Weaver

Associate Professor

baweaver@wisc.edu

Phone: (608) 263-5309

RESEARCH INTERESTS - Regulation of chromosome segregation during mitosis

 

Address: 6109 WIMR – 1111 Highland Ave. – Madison, WI 53705 
Visit the Weaver Lab

 

PubMed

Education

B.S., Brown University
Ph.D., University of California, San Diego
Postdoctoral Research, Ludwig Institute for Cancer Research

Research 

  • Genes required for accurate chromosome segregation;
  • The types of chromosome segregation errors that drive tumor promotion versus tumor suppression; and
  • The context-dependent factors that influence the effects of aneuploidy on normal cells and on tumors

Representative Publications

  • Burkard ME, Weaver BA. Tuning Chromosomal Instability to Optimize Tumor Fitness. Cancer Discov. 2017 Feb;7(2):134-136.
  • Funk LC, Zasadil LM, Weaver BA. Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression. Dev Cell. 2016 Dec 19;39(6):638-652. Review.
  • Zasadil LM, Britigan EM, Ryan SD, Kaur C, Guckenberger DJ, Beebe DJ, Moser AR, Weaver BA. (2016) High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation. Mol Biol Cell. 27(13):1981-9.
  • Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. (2016) Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 16:47.
  • Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. (2016) Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 15:48-59.
  • Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EW, Choi EY, Cingolani G, Weaver BA, Miyamoto S. (2015) IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. J Biol Chem. 290:17967-84.
  • Wan J, Weaver BA. (2015) Mad1 at the Golgi apparatus: a story beyond kinetochores. Cell Cycle. 14:1763-4.
  • Wan J, Zhu F, Zasadil LM, Yu J, Wang L, Johnson A, Berthier E, Beebe DJ, Audhya A, Weaver BA. (2014) A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol. 24:2687-92.
  • Weaver BA. (2014) How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 25:2677-81.
  • Britigan EM, Wan J, Zasadil LM, Ryan SD, Weaver BA. (2014) The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell. 25:2761-73.
  • Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. (2014) Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 6:229ra43.
  • Choudhary A, Lera RF, Martowicz ML, Oxendine K, Laffin JJ, Weaver BA, Burkard ME. (2013) Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 110:13026-31.
  • Zasadil LM, Britigan EM, Weaver BA. (2013) 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol. 24:370-9.
  • Harkness T, Weaver BA, Alexander CM, Ogle BM. (2013) Cell fusion in tumor
    development: accelerated genetic evolution. Crit Rev Oncog. 18:19-42.
    Review.
  • Ryan, S.D., Britigan, E.M.C., Zasadil, L.M., Witte, K., Audhya, A., Roopra, A. and Weaver, B.A.. (2012). Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci U S A., 109:E2205-14.
  • Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, and Cleveland DW. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 11:25-36.