Cell and Regenerative Biology
School of Medicine and Public Health

Beth Weaver

Position title: Professor

Email: baweaver@wisc.edu

Phone: Phone: (608) 263-5309

Address:
RESEARCH INTERESTS - Regulation of chromosome segregation during mitosis. Impact of chromosome missegregation on tumors

Headshot of Dr. Beth Weaver

 

Address: 6109 WIMR tower 1 – 1111 Highland Ave. – Madison, WI 53705 
Visit the Weaver Lab Website

 

PubMed

Education

B.S., Brown University
Ph.D., University of California, San Diego
Postdoctoral Research, Ludwig Institute for Cancer Research

Stage of Mitosis

Researchdiagram for Beth Weaver's page

  • Genes required for accurate chromosome segregation
  • Effects of radiation and chemotherapy on mitosis; biomarkers of response
  • Types and rates of chromosome segregation errors that drive tumor promotion versus tumor suppression

Representative Publications

  • Singh A, Denu RA, Wolfe SK, Sperger JM, Schehr J, Witkowsky T, Esbona K, Chappell RJ, Weaver BA, Burkard ME, Lang JM 2020. Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer. Mol Oncol. doi: 10.1002/1878-0261.12687.
  • Johnson JM, Hebert AS, Drane QH, Lera RF, Wan J, Weaver BA, Coon JJ, Burkard ME. 2020. A Genetic Toggle for Chemical Control of Individual Plk1 Substrates. Cell Chem Biol 19: 350-362.
  • Denomy C, Germain S, Haave B, Vizeacoumar FS, Freywald A, Weaver BA, Vizeacoumar FJ. 2019. Banding Together: A Systematic Comparison of The Cancer Genome Atlas and the Mitelman Database. Cancer Res 79: 5181-5190.
  • Wan J, Block S, Scribano CM, Thiry R, Esbona K, Audhya A, Weaver BA. Mad1 destabilizes p53 by preventing PML from sequestering MDM2. Nature Commun 10: 1540-1553.
  • Burkard ME, Weaver BA. Tuning Chromosomal Instability to Optimize Tumor Fitness. Cancer Discov. 2017 Feb;7(2):134-136.
  • Funk LC, Zasadil LM, Weaver BA. Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression. Dev Cell. 2016 Dec 19;39(6):638-652. Review.
  • Zasadil LM, Britigan EM, Ryan SD, Kaur C, Guckenberger DJ, Beebe DJ, Moser AR, Weaver BA. (2016) High rates of chromosome missegregation suppress tumor progression but do not inhibit tumor initiation. Mol Biol Cell. 27(13):1981-9.
  • Denu RA, Zasadil LM, Kanugh C, Laffin J, Weaver BA, Burkard ME. (2016) Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer. BMC Cancer. 16:47.
  • Choudhary A, Zachek B, Lera RF, Zasadil LM, Lasek A, Denu RA, Kim H, Kanugh C, Laffin JJ, Harter JM, Wisinski KB, Saha S, Weaver BA, Burkard ME. (2016) Identification of Selective Lead Compounds for Treatment of High-Ploidy Breast Cancer. Mol Cancer Ther. 15:48-59.
  • Hwang B, McCool K, Wan J, Wuerzberger-Davis SM, Young EW, Choi EY, Cingolani G, Weaver BA, Miyamoto S. (2015) IPO3-mediated Nonclassical Nuclear Import of NF-κB Essential Modulator (NEMO) Drives DNA Damage-dependent NF-κB Activation. J Biol Chem. 290:17967-84.
  • Wan J, Weaver BA. (2015) Mad1 at the Golgi apparatus: a story beyond kinetochores. Cell Cycle. 14:1763-4.
  • Wan J, Zhu F, Zasadil LM, Yu J, Wang L, Johnson A, Berthier E, Beebe DJ, Audhya A, Weaver BA. (2014) A Golgi-localized pool of the mitotic checkpoint component Mad1 controls integrin secretion and cell migration. Curr Biol. 24:2687-92.
  • Weaver BA. (2014) How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 25:2677-81.
  • Britigan EM, Wan J, Zasadil LM, Ryan SD, Weaver BA. (2014) The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B. Mol Biol Cell. 25:2761-73.
  • Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. (2014) Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Sci Transl Med. 6:229ra43.
  • Choudhary A, Lera RF, Martowicz ML, Oxendine K, Laffin JJ, Weaver BA, Burkard ME. (2013) Interphase cytofission maintains genomic integrity of human cells after failed cytokinesis. Proc Natl Acad Sci U S A. 110:13026-31.
  • Zasadil LM, Britigan EM, Weaver BA. (2013) 2n or not 2n: Aneuploidy, polyploidy and chromosomal instability in primary and tumor cells. Semin Cell Dev Biol. 24:370-9.
  • Harkness T, Weaver BA, Alexander CM, Ogle BM. (2013) Cell fusion in tumor development: accelerated genetic evolution. Crit Rev Oncog. 18:19-42. Review.
  • Ryan, S.D., Britigan, E.M.C., Zasadil, L.M., Witte, K., Audhya, A., Roopra, A. and Weaver, B.A.. (2012). Up-regulation of the mitotic checkpoint component Mad1 causes chromosomal instability and resistance to microtubule poisons. Proc Natl Acad Sci U S A., 109:E2205-14.
  • Weaver BA, Silk AD, Montagna C, Verdier-Pinard P, and Cleveland DW. (2007). Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell. 11:25-36.